公开(公告)号：US09353117B2

公开(公告)日：2016-05-31

申请号：US13991816

申请日：2011-12-08

申请人： Juan Jose Marugan ,  Noel Southall ,  Ehud Goldin ,  Wei Zheng ,  Samarjit Patnaik ,  Ellen Sidransky ,  Omid Motabar ,  Wendy Westbroek

发明人： Juan Jose Marugan ,  Noel Southall ,  Ehud Goldin ,  Wei Zheng ,  Samarjit Patnaik ,  Ellen Sidransky ,  Omid Motabar ,  Wendy Westbroek

IPC分类号： A61K31/519 ,  C07D487/04

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61P43/00 ,  C07D487/04

摘要： Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I) in which variables R1-R7 and X are described in the application.

摘要翻译： 本文描述了取代的吡唑并嘧啶和二氢吡唑并嘧啶及其相关化合物，其制备方法，含有这些化合物的组合物，以及这些化合物在治疗溶酶体贮积症如戈谢病中的应用方法。 化合物是通式（I），其中变量R1-R7和X在本申请中描述。

公开(公告)号：US20140249145A1

公开(公告)日：2014-09-04

申请号：US13991816

申请日：2011-12-08

申请人： Juan Jose Marugan ,  Noel Southall ,  Ehud Goldin ,  Wei Zheng ,  Samarjit Patnaik ,  Ellen Sidransky ,  Omid Motabar ,  Wendy Westbroek

发明人： Juan Jose Marugan ,  Noel Southall ,  Ehud Goldin ,  Wei Zheng ,  Samarjit Patnaik ,  Ellen Sidransky ,  Omid Motabar ,  Wendy Westbroek

IPC分类号： C07D487/04

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61P43/00 ,  C07D487/04

摘要： Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I) in which variables R1-R7 and X are described in the application.

摘要翻译： 本文描述了取代的吡唑并嘧啶和二氢吡唑并嘧啶及其相关化合物，其制备方法，含有这些化合物的组合物，以及这些化合物在治疗溶酶体贮积症如戈谢病中的应用方法。 化合物是通式（I），其中变量R1-R7和X在本申请中描述。

公开(公告)号：US20120065147A1

公开(公告)日：2012-03-15

申请号：US13320729

申请日：2010-05-12

申请人： Olivier De Wever ,  An Hendrix ,  Wendy Westbroek

发明人： Olivier De Wever ,  An Hendrix ,  Wendy Westbroek

IPC分类号： A61K38/10 ,  C12Q1/68 ,  G01N33/566 ,  A61P35/00 ,  C07K7/08 ,  C07H21/02 ,  A61K31/7088 ,  C12Q1/34 ,  G01N33/53

CPC分类号： G01N33/57415 ,  C07K14/82 ,  C12N15/1135 ,  C12N2310/14 ,  G01N2333/4719

摘要： The present invention relates to evaluating the prognosis of patients with estrogen receptor-positive breast cancer on the basis of Rab27B expression. The invention further relates to a kit comprising an assay for measuring Rab27B levels in said patients and to the usage of Rab27B as a target to screen for drugs capable of inhibiting or diminishing metastasis of said cancer. Furthermore, the invention discloses compounds which can be used to treat estrogen receptor-positive breast cancer.

摘要翻译： 本发明涉及基于Rab27B表达来评估雌激素受体阳性乳腺癌患者的预后。 本发明进一步涉及一种试剂盒，其包含用于测量所述患者中的Rab27B水平的测定法，以及Rab27B作为靶标筛选能够抑制或减少所述癌症转移的药物的用途。 此外，本发明公开了可用于治疗雌激素受体阳性乳腺癌的化合物。

公开(公告)号：US20090239934A1

公开(公告)日：2009-09-24

申请号：US12086242

申请日：2006-12-12

申请人： Anne-Marie Schmitt-Milas ,  Jo Lambert ,  Wendy Westbroek ,  Mireille Van Gele

发明人： Anne-Marie Schmitt-Milas ,  Jo Lambert ,  Wendy Westbroek ,  Mireille Van Gele

IPC分类号： A61K31/7088 ,  C07H21/02

CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/3231

摘要： The present invention relates to novel isolated siRNAs comprising a sense RNA strand and a complementary antisense RNA strand which together form an RNA duplex, characterized in that the sense RNA strand comprises a sequence which has at most one nucleotide that is distinct in relation to a fragment of 14 to 30 contiguous nucleotides of the nucleotide sequence of exon F of the gene encoding the myosin Va protein, and also to compositions comprising at least one such siRNA, and to the use of at least one such siRNA as a cosmetic or therapeutic agent for skin depigmentation.

摘要翻译： 本发明涉及包含一起形成RNA双链体的正义RNA链和互补反义RNA链的新型分离的siRNA，其特征在于有义RNA链包含至少一个与片段不同的核苷酸的序列 编码肌球蛋白Va蛋白的基因的外显子F的核苷酸序列的14至30个连续核苷酸，以及包含至少一种这样的siRNA的组合物，以及使用至少一种这样的siRNA作为化妆品或治疗剂 皮肤色素沉着

公开(公告)号：US09103833B2

公开(公告)日：2015-08-11

申请号：US13320729

申请日：2010-05-12

申请人： Olivier De Wever ,  An Hendrix ,  Wendy Westbroek

发明人： Olivier De Wever ,  An Hendrix ,  Wendy Westbroek

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  C07K14/82 ,  C12N15/113

CPC分类号： G01N33/57415 ,  C07K14/82 ,  C12N15/1135 ,  C12N2310/14 ,  G01N2333/4719

摘要： The present invention relates to evaluating the prognosis of patients with estrogen receptor-positive breast cancer on the basis of Rab27B expression. The invention further relates to a kit comprising an assay for measuring Rab27B levels in said patients and to the usage of Rab27B as a target to screen for drugs capable of inhibiting or diminishing metastasis of said cancer. Furthermore, the invention discloses compounds which can be used to treat estrogen receptor-positive breast cancer.

摘要翻译： 本发明涉及基于Rab27B表达来评估雌激素受体阳性乳腺癌患者的预后。 本发明进一步涉及一种试剂盒，其包含用于测量所述患者中的Rab27B水平的测定法，以及Rab27B作为靶标筛选能够抑制或减少所述癌症转移的药物的用途。 此外，本发明公开了可用于治疗雌激素受体阳性乳腺癌的化合物。

公开(公告)号：US07999096B2

公开(公告)日：2011-08-16

申请号：US12086242

申请日：2006-12-12

申请人： Anne-Marie Schmitt-Milas ,  Jo Lambert ,  Wendy Westbroek ,  Mireille Van Gele

发明人： Anne-Marie Schmitt-Milas ,  Jo Lambert ,  Wendy Westbroek ,  Mireille Van Gele

IPC分类号： C07H21/04

CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/3231

摘要： The present invention relates to novel isolated siRNAs comprising a sense RNA strand and a complementary antisense RNA strand which together form an RNA duplex, characterized in that the sense RNA strand comprises a sequence which has at most one nucleotide that is distinct in relation to a fragment of 14 to 30 contiguous nucleotides of the nucleotide sequence of exon F of the gene encoding the myosin Va protein, and also to compositions comprising at least one such siRNA, and to the use of at least one such siRNA as a cosmetic or therapeutic agent for skin depigmentation.

摘要翻译： 本发明涉及包含一起形成RNA双链体的正义RNA链和互补反义RNA链的新型分离的siRNA，其特征在于有义RNA链包含至少一个与片段不同的核苷酸的序列 编码肌球蛋白Va蛋白的基因的外显子F的核苷酸序列的14至30个连续核苷酸，以及包含至少一种这样的siRNA的组合物，以及使用至少一种这样的siRNA作为化妆品或治疗剂 皮肤色素沉着