发明授权
- 专利标题： Intermediates for producing NEP inhibitors or prodrugs thereof
- 专利标题（中）： 用于生产NEP抑制剂的中间体或其前药
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申请号： US14939513申请日： 2015-11-12
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公开(公告)号： US09403766B2公开(公告)日： 2016-08-02
- 发明人: David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
- 申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
- 申请人地址： CH Basel
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： CH Basel
- 代理商 David R. Kurlandsky
- 优先权： EP08150353 20080117
- 主分类号： C07D207/26
- IPC分类号： C07D207/26 ; C07D207/38 ; C07D207/263 ; C07D207/36 ; C07D403/06 ; C07C271/22
摘要：
The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
公开/授权文献
- US20160060217A1 Processes 公开/授权日：2016-03-03
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