发明授权
US09434670B2 Family of aryl, heteroaryl, O-aryl and O-heteroaryl carbasugars
有权
芳基,杂芳基,O-芳基和O-杂芳基碳原子的族
- 专利标题: Family of aryl, heteroaryl, O-aryl and O-heteroaryl carbasugars
- 专利标题(中): 芳基,杂芳基,O-芳基和O-杂芳基碳原子的族
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申请号: US14119265申请日: 2012-05-29
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公开(公告)号: US09434670B2公开(公告)日: 2016-09-06
- 发明人: Geraldine Deliencourt-Godefroy , Lenaig Lopes
- 申请人: Geraldine Deliencourt-Godefroy , Lenaig Lopes
- 申请人地址: FR Val de Reuil
- 专利权人: TFCHEM
- 当前专利权人: TFCHEM
- 当前专利权人地址: FR Val de Reuil
- 代理机构: Foley & Lardner LLP
- 优先权: EP11305645 20110526
- 国际申请: PCT/EP2012/060050 WO 20120529
- 国际公布: WO2012/160218 WO 20121129
- 主分类号: C07C43/29
- IPC分类号: C07C43/29 ; A61K31/085 ; C07C43/225 ; C07C43/23 ; C07C43/247 ; C07C43/253 ; C07D231/20 ; C07D333/16 ; A61K8/34 ; A61K8/49 ; A61Q19/02 ; C07C41/09 ; C07C41/22 ; C07C41/24
摘要:
The present invention relates to a compound of the following formula (I): as well as its process of preparation, pharmaceutical and cosmetics composition comprising it and use thereof, notably as an inhibitor of the sodium-dependent glucose co-transporter, such as SGLT1, SGLT2 and SGLT3, in particular in the treatment or prevention of diabetes, and more particularly type-II diabetes, diabetes-related complications, such as arthritis of the lower extremities, cardiac infarction, renal insufficiency, neuropathy or blindness, hyperglycemia, hyperinsulinemia, obesity, hypertriglyceridemia, X syndrome and arteriosclerosis, as well as for its use as an anticancer, anti-infective, anti-viral, anti-thrombotic or anti-inflammatory drug, or for lightening, bleaching, depigmenting the skin, removing blemishes from the skin, particularly age spots and freckles, or preventing pigmentation of the skin.
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