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    FAMILY OF ARYL, HETEROARYL, O-ARYL AND O-HETEROARYL CARBASUGARS
    2.
    发明申请
    FAMILY OF ARYL, HETEROARYL, O-ARYL AND O-HETEROARYL CARBASUGARS 有权
    ARYL，HETEROARYL，O-ARYL和O-HETEROARYL CARBASUGARS家族

    公开(公告)号：US20140105839A1

    公开(公告)日：2014-04-17

    申请号：US14119265

    申请日：2012-05-29

    申请人： Geraldine Deliencourt-Godefroy ,  Lenaig Lopes

    发明人： Geraldine Deliencourt-Godefroy ,  Lenaig Lopes

    IPC分类号： C07C43/29 ,  C07D333/16 ,  A61K8/34 ,  A61Q19/02 ,  C07C41/24 ,  C07C43/253 ,  C07C43/225 ,  C07C41/22 ,  C07C41/09 ,  C07D231/20 ,  A61K8/49

    CPC分类号： C07C43/29 ,  A61K8/347 ,  A61K8/494 ,  A61K8/4946 ,  A61K8/4986 ,  A61K8/69 ,  A61Q19/02 ,  C07C41/09 ,  C07C41/22 ,  C07C41/24 ,  C07C43/225 ,  C07C43/23 ,  C07C43/247 ,  C07C43/253 ,  C07D231/20 ,  C07D333/16

    摘要： The present invention relates to a compound of the following formula (I): as well as its process of preparation, pharmaceutical and cosmetics composition comprising it and use thereof, notably as an inhibitor of the sodium-dependent glucose co-transporter, such as SGLT1, SGLT2 and SGLT3, in particular in the treatment or prevention of diabetes, and more particularly type-II diabetes, diabetes-related complications, such as arthritis of the lower extremities, cardiac infarction, renal insufficiency, neuropathy or blindness, hyperglycemia, hyperinsulinemia, obesity, hypertriglyceridemia, X syndrome and arteriosclerosis, as well as for its use as an anticancer, anti-infective, anti-viral, anti-thrombotic or anti-inflammatory drug, or for lightening, bleaching, depigmenting the skin, removing blemishes from the skin, particularly age spots and freckles, or preventing pigmentation of the skin.

    摘要翻译： 本发明涉及以下式（I）的化合物及其制备方法，包含其的药物和化妆品组合物及其用途，特别是作为钠依赖型葡萄糖共转运体的抑制剂，例如SGLT1 特别是糖尿病的治疗或预防，特别是II型糖尿病，糖尿病相关并发症如下肢关节炎，心肌梗塞，肾功能不全，神经病变或失明，高血糖症，高胰岛素血症， 肥胖症，高甘油三酯血症，X综合征和动脉硬化，以及其用作抗癌，抗感染，抗病毒，抗血栓形成或抗炎药物，或用于减轻，漂白，脱色皮肤，从 皮肤，特别是老年斑和雀斑，或防止皮肤色素沉着。

    GEM-DIFLUORINATED C-ISOPROPYLGALACTOSIDE DERIVATES
    5.
    发明申请
    GEM-DIFLUORINATED C-ISOPROPYLGALACTOSIDE DERIVATES 有权
    GEM-衍生的C-异丙基乳糖苷衍生物

    公开(公告)号：US20140199727A1

    公开(公告)日：2014-07-17

    申请号：US14237490

    申请日：2012-08-08

    申请人： Geraldine Deliencourt-Godefroy ,  Hyacinthe Fillon

    发明人： Geraldine Deliencourt-Godefroy ,  Hyacinthe Fillon

    IPC分类号： C12N15/63 ,  C07H7/02 ,  C12P21/00

    CPC分类号： C12N15/635 ,  C07D309/10 ,  C07H7/02 ,  C12N15/72 ,  C12P21/00

    摘要： The present invention concerns compounds of the following formula (I) or a pharmaceutically acceptable salt thereof, a stereoisomer or a mixture of stereoisomers in any proportion, in particular a mixture of enantiomers, and particularly a racemate mixture, in which R represents H, OH or OR19, as well as processes for preparing these compounds and their use as inducer for the transcription of genes under control of the lac promoter.

    摘要翻译： 本发明涉及下列通式（I）的化合物或其药学上可接受的盐，立体异构体或任何比例的立体异构体混合物，特别是对映体混合物，特别是外消旋物混合物，其中R代表H，OH 或OR19，以及制备这些化合物的方法及其作为诱导剂用于在lac启动子控制下转录基因的用途。