发明授权
- 专利标题： Complement factor B inhibitors and uses there of
- 专利标题（中）： 补体因子B抑制剂及其用途
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申请号： US14774430申请日： 2014-03-13
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公开(公告)号： US09475806B2公开(公告)日： 2016-10-25
- 发明人: Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang
- 申请人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理商 John B. Alexander
- 国际申请： PCT/US2014/026875 WO 20140313
- 国际公布： WO2014/143638 WO 20140918
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; A61K31/4353 ; A61K31/437 ; C07D471/04
摘要：
The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.
公开/授权文献
- US20160024079A1 Complement Factor B inhibitors and uses there of 公开/授权日：2016-01-28