专利检索 ap:"Christopher Michael Adams" 第 1 页

1.

发明授权
Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof 有权

公开(公告)号：US09682968B2

公开(公告)日：2017-06-20

申请号：US14904694

申请日：2014-07-14

申请人： Christopher Michael Adams , Michael Paul Capparelli , Takeru Ehara , Rajeshri Ganesh Karki , Nello Mainolfi , Chun Zhang

发明人： Christopher Michael Adams , Michael Paul Capparelli , Takeru Ehara , Rajeshri Ganesh Karki , Nello Mainolfi , Chun Zhang

IPC分类号： C07D401/06 , A61K31/55 , C07D413/06 , C07D401/14 , C07D413/14 , C07D403/06 , C07D417/14 , A61K31/404 , A61K31/438 , A61K31/4439 , A61K31/454 , A61K31/5377

CPC分类号： C07D413/06 , A61K31/404 , A61K31/438 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/55 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14 , C07D417/14

摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitors of the complement alternative pathway, in particular of Factor B. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

2.

发明申请
Complement Factor B inhibitors and uses there of 有权
标题翻译：补体因子B抑制剂及其用途

公开(公告)号：US20160024079A1

公开(公告)日：2016-01-28

申请号：US14774430

申请日：2014-03-13

申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG

发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.

摘要翻译： 本发明提供了式（I）化合物：其中X为N或CH，Y为NH，O或S，制备这些化合物的方法及其作为因子B抑制剂用于治疗与补体相关的病症和疾病的用途替代途径激活如年龄相关性黄斑变性，糖尿病性视网膜病变和相关眼科疾病。本发明还提供药物组合物和药理活性剂的组合。

3.

发明授权
Complement pathway modulators and uses thereof 有权

公开(公告)号：US09056874B2

公开(公告)日：2015-06-16

申请号：US13826725

申请日：2013-03-14

申请人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang

发明人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang

IPC分类号： C07D403/06 , C07D403/04 , C07D403/08 , C07D403/14 , C07D401/14 , C07D413/14 , C07D487/04 , C07D491/048 , A61K31/4184 , C07D413/06 , A61K31/423 , A61K31/4439 , A61K45/06

CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/06 , C07D413/14 , C07D487/04 , C07D491/048

摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

4.

发明授权
Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators 有权
标题翻译：四氢吡啶 - 吡啶和四氢吡啶 - 嘧啶化合物及其作为C5a受体调节剂的用途

公开(公告)号：US08846656B2

公开(公告)日：2014-09-30

申请号：US13553120

申请日：2012-07-19

申请人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay

发明人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay

IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08

CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107

摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式I化合物：（I）制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

5.

发明申请
TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS 有权
标题翻译：四氢吡啶并吡啶和四氢吡啶并吡啶化合物及其作为C5A受体调节剂的用途

公开(公告)号：US20130184253A1

公开(公告)日：2013-07-18

申请号：US13553120

申请日：2012-07-19

申请人： Christopher Michael ADAMS , Veronique DARSIGNY , Alec Nathanson FLYER , Christine Fang GELIN , Timothy Brian Hurley , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Erik MEREDITH , Chang RAO , Michael H. SERRANO-WU , Catherine Fooks SOLOVAY

发明人： Christopher Michael ADAMS , Veronique DARSIGNY , Alec Nathanson FLYER , Christine Fang GELIN , Timothy Brian Hurley , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Erik MEREDITH , Chang RAO , Michael H. SERRANO-WU , Catherine Fooks SOLOVAY

IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08

CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107

摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式I化合物：（I）制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

6.

发明申请
INFLATABLE MEDICAL DEVICES 审中-公开

公开(公告)号：US20100241178A1

公开(公告)日：2010-09-23

申请号：US12477048

申请日：2009-06-02

申请人： Alexander Quillin TILSON , Mark Christopher SCHEEFF , Roland J. DOWNS , Christopher Michael ADAMS , Jon Michael HOLWEGER

发明人： Alexander Quillin TILSON , Mark Christopher SCHEEFF , Roland J. DOWNS , Christopher Michael ADAMS , Jon Michael HOLWEGER

IPC分类号： A61B17/56 , A61M29/02

CPC分类号： A61M29/02 , A61B17/8816 , A61B17/8827 , A61B17/8833 , A61B17/8855 , A61F5/0036 , A61M25/0147 , A61M25/1002 , A61M25/1027 , A61M25/1029 , A61M2025/1031 , A61M2025/1072 , A61M2025/1075 , A61M2025/1086 , A61M2025/1088 , A61M2025/1093 , A61M2025/1097 , A61M2210/02 , A61M2210/125 , B29C41/04 , B29C41/14 , Y10T156/1028 , Y10T156/108

摘要： Inflatable medical devices and methods for making and using the same are disclosed. The inflatable medical devices can be medical balloons. The balloons can be configured to have a through-lumen or no through-lumen and a wide variety of geometries. The device can have a high-strength, non-compliant, fiber-reinforced, multi-layered wall. The inflatable medical device can be used for angioplasty, kyphoplasty, percutaneous aortic valve replacement, or other procedures described herein.

7.

发明申请
INFLATABLE MEDICAL DEVICES 有权

公开(公告)号：US20100241153A1

公开(公告)日：2010-09-23

申请号：US12477077

申请日：2009-06-02

申请人： Alexander Quillin TILSON , Mark Christopher SCHEEFF , Roland J. DOWNS , Christopher Michael ADAMS , Jon Michael HOLWEGER

发明人： Alexander Quillin TILSON , Mark Christopher SCHEEFF , Roland J. DOWNS , Christopher Michael ADAMS , Jon Michael HOLWEGER

IPC分类号： A61M29/02

CPC分类号： A61M29/02 , A61B17/8816 , A61B17/8827 , A61B17/8833 , A61B17/8855 , A61F5/0036 , A61M25/0147 , A61M25/1002 , A61M25/1027 , A61M25/1029 , A61M2025/1031 , A61M2025/1072 , A61M2025/1075 , A61M2025/1086 , A61M2025/1088 , A61M2025/1093 , A61M2025/1097 , A61M2210/02 , A61M2210/125 , B29C41/04 , B29C41/14 , Y10T156/1028 , Y10T156/108

摘要： Inflatable medical devices and methods for making and using the same are disclosed. The inflatable medical devices can be medical balloons. The balloons can be configured to have a through-lumen or no through-lumen and a wide variety of geometries. The device can have a high-strength, non-compliant, fiber-reinforced, multi-layered wall. The inflatable medical device can be used for angioplasty, kyphoplasty, percutaneous aortic valve replacement, or other procedures described herein.

8.

发明申请
Complement pathway modulators and uses thereof 审中-公开

公开(公告)号：US20150250767A1

公开(公告)日：2015-09-10

申请号：US14715594

申请日：2015-05-19

申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG

发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG

IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/4245

CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/06 , C07D413/14 , C07D487/04 , C07D491/048

摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

9.

发明申请
ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物

公开(公告)号：US20140288126A1

公开(公告)日：2014-09-25

申请号：US14288699

申请日：2014-05-28

申请人： Christopher Michael ADAMS , Qi-Ying HU , Leslie Wighton MCQUIRE , Julien Papillon

发明人： Christopher Michael ADAMS , Qi-Ying HU , Leslie Wighton MCQUIRE , Julien Papillon

IPC分类号： C07D401/14 , A61K31/4439 , A61K45/06 , C07D401/04

CPC分类号： C07D401/14 , A61K31/4439 , A61K45/06 , C07D213/61 , C07D401/04 , C07D401/06 , C07D401/12 , A61K2300/00

摘要： The present invention provides novel organic compounds of Formula (I): methods of use, and pharmaceutical compositions thereof.

摘要翻译： 本发明提供新的式（I）有机化合物：其使用方法及其药物组合物。