Apparatus and methods for transceiver interface overvoltage clamping are provided. In certain configurations, an interface device includes a first p-type well region and a second p-type well region in an n-type isolation structure. Additionally, the clamp device includes a first p-type active region and a first n-type active region in the first p-type well region and electrically connected to a first terminal of the clamp device. Furthermore, the clamp device includes a second p-type active region and a second n-type active region in the second p-type well region and electrically connected to a second terminal of the clamp device. The n-type isolation structure is in a p-type region of a semiconductor substrate, and electrically isolates the first and second p-type well regions from the p-type substrate region. The clamp device further includes a blocking voltage tuning structure positioned between the first and second n-type active regions.