Invention Grant
- Patent Title: Carbamate compounds and of making and using same
- Patent Title (中): 氨基甲酸酯化合物及其制备和使用
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Application No.: US14369982Application Date: 2013-01-07
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Publication No.: US09487495B2Publication Date: 2016-11-08
- Inventor: Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
- Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
- Applicant Address: US CA La Jolla US CA San Diego
- Assignee: THE SCRIPTS RESEARCH INSTITUTE,ABIDE THERAPEUTICS
- Current Assignee: THE SCRIPTS RESEARCH INSTITUTE,ABIDE THERAPEUTICS
- Current Assignee Address: US CA La Jolla US CA San Diego
- Agency: Wilson, Sonsini, Goodrich & Rosati
- International Application: PCT/US2013/020551 WO 20130107
- International Announcement: WO2013/103973 WO 20130711
- Main IPC: C07D295/205
- IPC: C07D295/205 ; C07D317/46 ; C07D317/58 ; C07D401/06 ; C07D403/06 ; C07D407/06 ; C07D413/06 ; A61K31/495 ; A61K31/496 ; C07D295/26 ; C07D405/14 ; C07D215/42 ; C07D213/40 ; C07C271/12 ; C07D231/12 ; C07D231/16 ; C07D231/56 ; C07D241/04 ; C07D471/04 ; C07D471/10 ; C07D261/08 ; C07D487/04 ; C07D263/32 ; C07D205/04 ; C07D491/107 ; C07D207/14 ; C07D271/06 ; C07D307/79 ; C07D213/55 ; C07D401/04 ; C07C271/10 ; C07D207/09

Abstract:
This disclosure provides compounds having the structure: wherein L3, R7, Rd and p are defined herein, which are modulators of MAGL and/or ABHD6. Further provided is the use of these compounds as medicinal agents, processes for their preparation, and pharmaceutical compositions that include the disclosed compounds. The disclosure also provides a method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
Public/Granted literature
- US20150018335A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME Public/Granted day:2015-01-15
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