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公开(公告)号:US09981972B2
公开(公告)日:2018-05-29
申请号:US15313012
申请日:2015-05-20
Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
Inventor: Benjamin F. Cravatt , Armand B. Cognetta , Jonathan J. Hulce , Micah J. Niphakis , Todd K. Jones , Cheryl A. Grice
IPC: C07D401/12 , C07D401/14 , C07D413/14 , C07D487/04 , C07D471/04 , C12Q1/34
CPC classification number: C07D487/04 , C12Q1/34
Abstract: Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases. Furthermore, the subject compounds and compositions are useful for the treatment of one or more of cancer, pain, diabetes, obesity/metabolic syndrome, epilepsy, traumatic brain injury, and inflammation.
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公开(公告)号:US09567302B2
公开(公告)日:2017-02-14
申请号:US14383076
申请日:2013-03-15
Applicant: Abide Therapeutics, Inc. , The Scripps Research Institute
Inventor: Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Dong-Hui Wang , Olivia Weber , Benjamin F. Cravatt , Micah J. Niphakis , Armand Cognetta , Jae Won Chang
IPC: C07D207/46 , C07D401/12 , C07D405/14 , C07D413/12 , C07D413/14 , A61K31/496 , A61K31/454 , C07D403/12 , C07D401/14 , C07D491/08 , C07D233/80 , C07D403/14 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107 , C07D498/08 , C07D209/48
CPC classification number: C07D207/46 , C07D209/48 , C07D233/80 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.
Abstract translation: 本文提供了可用于治疗例如疼痛,实体瘤和/或肥胖症的氨基甲酸酯化合物。
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公开(公告)号:US09487495B2
公开(公告)日:2016-11-08
申请号:US14369982
申请日:2013-01-07
Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
Inventor: Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/205 , C07D317/46 , C07D317/58 , C07D401/06 , C07D403/06 , C07D407/06 , C07D413/06 , A61K31/495 , A61K31/496 , C07D295/26 , C07D405/14 , C07D215/42 , C07D213/40 , C07C271/12 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D213/55 , C07D401/04 , C07C271/10 , C07D207/09
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds having the structure: wherein L3, R7, Rd and p are defined herein, which are modulators of MAGL and/or ABHD6. Further provided is the use of these compounds as medicinal agents, processes for their preparation, and pharmaceutical compositions that include the disclosed compounds. The disclosure also provides a method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
Abstract translation: 本公开提供了可以是MAGL和/或ABHD6的调节剂的化合物和组合物及其作为药物的用途,其制备方法和包含公开的化合物作为至少一种活性剂的药物组合物。 本公开还提供了治疗有需要的患者的方法,其中患者患有诸如疼痛,实体瘤癌症和/或肥胖的适应症,其包括施用所公开的化合物或组合物。
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公开(公告)号:US20150148330A1
公开(公告)日:2015-05-28
申请号:US14599105
申请日:2015-01-16
Applicant: Abide Therapeutics, Inc. , The Scripps Research Institute
Inventor: Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/26 , C07D487/04 , C07D471/04 , C07D263/32 , C07D471/10 , C07D317/58 , C07C271/10 , C07D241/04 , C07D207/09 , C07D491/107 , C07D231/56
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
Abstract translation: 本公开提供了可以是MAGL和/或ABHD6的调节剂的化合物和组合物及其作为药物的用途,其制备方法和包含公开的化合物作为至少一种活性剂的药物组合物。 本公开还提供了治疗有需要的患者的方法,其中患者患有诸如疼痛,实体瘤癌症和/或肥胖的适应症,其包括施用所公开的化合物或组合物。
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公开(公告)号:US09133148B2
公开(公告)日:2015-09-15
申请号:US14599105
申请日:2015-01-16
Applicant: Abide Therapeutics, Inc. , The Scripps Research Institute
Inventor: Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: A61K31/495 , A61K31/496 , C07D207/09 , C07D207/14 , C07D213/56 , C07D205/04 , C07D295/26 , C07D295/205 , C07D487/04 , C07D487/10 , C07D491/107 , C07D405/14 , C07D215/42 , C07D213/40 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D263/32 , C07D271/06 , C07D307/79 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides piperazine carbamates and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed piperazine carbamates as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
Abstract translation: 本公开提供哌嗪类氨基甲酸酯和可以是MAGL和/或ABHD6的调节剂的组合物及其作为药物的用途,其制备方法和包括公开的哌嗪氨基甲酸酯作为至少一种活性剂的药物组合物。 本公开还提供了治疗有需要的患者的方法,其中患者患有诸如疼痛,实体瘤癌症和/或肥胖的适应症,其包括施用所公开的化合物或组合物。
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公开(公告)号:US20150018335A1
公开(公告)日:2015-01-15
申请号:US14369982
申请日:2013-01-07
Applicant: ABIDE THERAPEUTICS, INC , THE SCRIPPS RESEARCH INSTITUTE
Inventor: Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/205 , C07D407/06 , C07D317/58 , C07D205/04 , C07D401/04 , C07D271/06 , C07D295/26 , C07D413/06 , C07D405/14 , C07D213/55
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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公开(公告)号:US09957242B2
公开(公告)日:2018-05-01
申请号:US15272313
申请日:2016-09-21
Applicant: Abide Therapeutics, Inc. , THE SCRIPPS RESEARCH INSTITUTE
Inventor: Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M Lum , Benjamin F. Cravatt
IPC: C07D213/55 , C07D231/12 , C07D261/08 , A61K31/496 , C07D295/205 , C07D405/14 , C07D215/42 , C07D213/40 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D295/26 , C07D307/79 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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公开(公告)号:US11897865B2
公开(公告)日:2024-02-13
申请号:US17055081
申请日:2019-05-14
Applicant: THE SCRIPPS RESEARCH INSTITUTE
Inventor: Daisuke Ogasawara , Taka-Aki Ichu , Jonathan Hulce , Benjamin F. Cravatt
IPC: C07D401/14 , C07D401/12 , C07D401/04 , C07D471/04 , C07D471/08
CPC classification number: C07D401/14 , C07D401/04 , C07D401/12 , C07D471/04 , C07D471/08
Abstract: Provided herein are compounds and compositions useful as modulators of ABHD12. Furthermore, the subject compounds and compositions are useful as immunotherapies in treating, for instance, cancer or infectious diseases.
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公开(公告)号:US10859585B2
公开(公告)日:2020-12-08
申请号:US16235096
申请日:2018-12-28
Applicant: THE SCRIPPS RESEARCH INSTITUTE
Inventor: Benjamin F. Cravatt , Micah J. Niphakis , Kenneth Lum , Bruno Correia , Armand Cognetta , Jonathan Hulce
Abstract: Disclosed herein are methods, compositions, probes, assays and kits for identifying a lipid binding protein as a drug binding target. Also disclosed herein are methods, compositions, and probes for mapping a ligand binding site on a lipid binding protein, identification of lipid binding proteins, generating drug-lipid binding protein profiles, high throughput drug screening, and identification of drugs as potential lipid binding protein ligands.
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公开(公告)号:US20200071277A1
公开(公告)日:2020-03-05
申请号:US16478444
申请日:2018-01-17
Applicant: The Scripps Research Institute
Inventor: Benjamin F. Cravatt , Christopher G. PARKER , Bruno CORREIA
IPC: C07D229/02 , G01N1/44 , G01N1/28 , G01N33/68 , C07D403/12 , C07D405/12 , C07D409/12 , C07D401/10 , C07C233/06 , C07D317/46 , C07D295/10
Abstract: Disclosed herein are methods for identifying proteins as targets for interaction with a small molecule ligand. Also disclosed herein are small molecule ligands and compositions for use in profiling druggable proteins.
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