Invention Grant
- Patent Title: Nonribosomal peptide synthetases
- Patent Title (中): 非核糖体肽合成酶
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Application No.: US14713662Application Date: 2015-05-15
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Publication No.: US09487763B2Publication Date: 2016-11-08
- Inventor: David H. Sherman , Michael Marie Kaufman-Schofield , Sunit Jain , Gregory Dick
- Applicant: REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: C12P17/18
- IPC: C12P17/18 ; C12N9/10 ; C12N9/00 ; C12N9/88 ; C12N9/02 ; C12N9/04 ; C12N15/52
Abstract:
The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS)-derived drug and analogs thereof. The invention provides polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS-derived drug, the polypeptides encoded by such polynucleotides, expression vectors comprising the polynucleotides, host cells comprising the polynucleotides or expression vectors, and kits comprising a host cell. Also provided is a method for the production of ET-743, the NRPS-derived drug.
Public/Granted literature
- US20150361470A1 NONRIBOSOMAL PEPTIDE SYNTHETASES Public/Granted day:2015-12-17
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