发明授权
- 专利标题： Cocrystal of piperacillin sodium and sulbactam sodium and preparation method thereof, as well as pharmaceutical compositions containing same and uses thereof
- 专利标题（中）： 哌拉西林钠和舒巴坦钠的晶体及其制备方法，以及含有其的药物组合物及其用途
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申请号： US14428239申请日： 2012-09-14
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公开(公告)号： US09499565B2公开(公告)日： 2016-11-22
- 发明人: Haiyong Wang , Jing Li
- 申请人： Haiyong Wang , Jing Li
- 申请人地址： CN Beijing
- 专利权人： BEIJING XINTIANYU TECHNOLOGY DEVELOPMENT CO., LTD.
- 当前专利权人： BEIJING XINTIANYU TECHNOLOGY DEVELOPMENT CO., LTD.
- 当前专利权人地址： CN Beijing
- 代理机构： Cooper & Dunham LLP
- 代理商 John P. White
- 国际申请： PCT/CN2012/081422 WO 20120914
- 国际公布： WO2014/040280 WO 20140320
- 主分类号： A61K31/43
- IPC分类号： A61K31/43 ; A61K31/496 ; C07D499/887 ; C07D499/00 ; C07D499/04 ; C07D499/68
摘要：
Provided in the present invention are a cocrystal of piperacillin sodium and sulbactam sodium and preparation method thereof, as well as pharmaceutical compositions containing the same and uses thereof in treating infections caused by drug-resistant bacteria, such as a “super bacterium” producing NDM-1 and the like. The cocrystal of piperacillin sodium and sulbactam sodium contains diffraction angles of 14.24°, 16.58°, 16.79°, 17.77°, 19.20°, 20.21°, 20.39°, 23.06°, 27.86° and 32.16° represented by 2θ in an X-ray powder diffraction analysis spectrum.
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