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公开(公告)号：US5885981A
公开(公告)日：1999-03-23
申请号：US470944
申请日：1995-06-06
IPC分类号： C07D499/897 , A61K31/43 , A61K31/431 , A61P31/04 , C07D499/04 , C07D499/88 , C07D499/887 , C07D499/893 , C07D477/06
CPC分类号： C07D499/88
摘要： Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the general formula: ##STR2## in which R.sub.1 is a hydrogen atom or linear or branched C.sub.1 --C.sub.6 alkyl group, R.sub.2 is a particular substituted or unsubstituted alkyl, aryl or aralkyl group, n is an integer of 1-6, Y is a 5- or 6-membered heterocyclic aliphatic group having 1 or 2 oxygen atoms in the ring thereof, and Z is a specific 5-substituted 2-oxo-1,3-dioxolen-4-yl group. Antibiotic compositions for oral administration are also described.
摘要翻译： 抗生素penem化合物由下式表示：其中R表示下列通式的基团：其中R 1为氢原子或直链或支链C 1 -C 6烷基，R 2为特定的取代或未取代的 烷基，芳基或芳烷基，n为1-6的整数，Y为其环中具有1或2个氧原子的5或6元杂环脂族基团，Z为特定的5-取代的2-氧代 -1,3-二氧杂环戊烯-4-基。 还描述了用于口服给药的抗生素组合物。
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公开(公告)号：US11084833B2
公开(公告)日：2021-08-10
申请号：US16340244
申请日：2017-10-10
发明人： Craig A. Townsend , Evan Lloyd
IPC分类号： A61K31/431 , A61K31/43 , C07D499/887 , A61P31/06 , A61P31/04 , A61K45/06
摘要： Antibacterial agents against D,D- and L,D-transpeptidases are disclosed. Pharmaceutical compositions and methods of using the same also are disclosed.
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公开(公告)号：US5830889A
公开(公告)日：1998-11-03
申请号：US971829
申请日：1993-02-19
IPC分类号： C07D499/897 , A61K31/43 , A61K31/431 , A61P31/04 , C07D499/04 , C07D499/88 , C07D499/887 , C07D499/893 , C07D499/32
CPC分类号： C07D499/88
摘要： Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the general formula: ##STR2## in which R.sub.1 is a linear or branched C.sub.1 -C.sub.6 alkyl group, R.sub.2 is a particular substituted or unsubstituted alkyl, aryl or aralkyl group, n is an integer of 1-6, Y is a 5- or 6-membered heterocyclic aliphatic group having 1 or 2 oxygen atoms in the ring thereof, and Z is a specific 5-substituted 2-oxo-1,3-dioxolen-4-yl group. Antibiotic compositions for oral administration are also described.
摘要翻译： PCT No.PCT / JP91 / 01098 Sec。 371日期：1993年2月19日 102（e）日期1993年2月19日PCT 1991年8月16日PCT PCT。 第WO92 / 03442号公报 日期：1992年3月5日抗生素Penem化合物由下式表示：其中R表示通式：其中R 1为直链或支链C 1 -C 6烷基，R 2为特定取代基 或未取代的烷基，芳基或芳烷基，n为1-6的整数，Y为其环中具有1或2个氧原子的5或6元杂环脂族基团，Z为特定的5-取代的2 - 氧代-1,3-二氧杂环戊烯-4-基。 还描述了用于口服给药的抗生素组合物。
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公开(公告)号：US4952690A
公开(公告)日：1990-08-28
申请号：US396783
申请日：1989-08-21
申请人： Jacques Gosteli , Ivan Ernest , Marc Lang , Robert B. Woodward
发明人： Jacques Gosteli , Ivan Ernest , Marc Lang , Robert B. Woodward
IPC分类号： A61K31/397 , A61K31/43 , A61P31/04 , C07D205/08 , C07D205/09 , C07D417/12 , C07D499/04 , C07D499/06 , C07D499/86 , C07D499/861 , C07D499/87 , C07D499/88 , C07D499/881 , C07D499/883 , C07D499/887 , C07D499/897 , C07F9/568
CPC分类号： C07D499/88 , C07D205/08 , C07D205/09 , C07F9/5683
摘要： The invention relates to azetidin-2-ones of the formula ##STR1## wherein R.sub.a represents hydroxy-lower alkyl, R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group, R.sub.2.sup.A together with the carbonyl group to which it is attached is a protected carboxyl group and Z' is oxygen, sulfhur or an optionally substituted methylidene group, functional groups in the radicals R.sub.a, R.sub.1 and Z' optionally being in protected form. The azetidinones are useful intermediates for the preparation of penem antibiotics.
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公开(公告)号：US20150072957A1
公开(公告)日：2015-03-12
申请号：US14541890
申请日：2014-11-14
发明人： Jan-Ji Lai , Jian-Qiao Gu , Pradip M. Pathare , Valdas Jurkauskas , Joseph Terracciano , Nicole Miller Damour
IPC分类号： C07D499/887 , A61K31/496 , A61K9/19 , A61K31/546 , A61K31/675 , A61K31/431 , A61K31/43
CPC分类号： C07D499/897 , A61K9/19 , A61K31/403 , A61K31/4188 , A61K31/43 , A61K31/431 , A61K31/4353 , A61K31/444 , A61K31/496 , A61K31/53 , A61K31/546 , A61K31/675 , C07D499/14 , C07D499/86 , Y02A50/473
摘要： This disclosure provides compositions containing solid forms of tazobactam arginine, and methods of manufacturing and using these compositions.
摘要翻译： 本公开提供了含有固体形式的他唑巴坦精氨酸的组合物，以及制造和使用这些组合物的方法。
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公开(公告)号：US5122604A
公开(公告)日：1992-06-16
申请号：US525817
申请日：1990-05-21
IPC分类号： A61K31/43 , C07D205/08 , C07D207/16 , C07D207/24 , C07D401/12 , C07D477/20 , C07D487/04 , C07D499/00 , C07D499/32 , C07D499/88 , C07D499/887 , C07F7/10 , C07F7/18 , C07F9/6561
CPC分类号： C07D477/20 , C07D205/08 , C07D207/16 , C07D207/24 , C07D401/12 , C07D499/88 , C07F7/10 , C07F7/186 , C07F9/65611 , Y02P20/55
摘要： Novel .beta.-lactam compounds belonging to carbapenem or penem derivatives useful as antimicrobial agents or intermediates therefor and a process for producing these compounds are disclosed.
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公开(公告)号：US4933333A
公开(公告)日：1990-06-12
申请号：US106035
申请日：1987-10-08
IPC分类号： A61K31/43 , C07D205/08 , C07D207/16 , C07D207/24 , C07D401/12 , C07D477/20 , C07D487/04 , C07D499/00 , C07D499/32 , C07D499/88 , C07D499/887 , C07F7/10 , C07F7/18 , C07F9/6561
CPC分类号： C07D477/20 , C07D205/08 , C07D207/16 , C07D207/24 , C07D401/12 , C07D499/88 , C07F7/10 , C07F7/186 , C07F9/65611 , Y02P20/55
摘要： Novel .beta.-lactam compounds belonging to carbapenem or penem derivatives useful as antimicrobial agents or intermediates therefor and a process for producing these compounds are disclosed.
摘要翻译： 公开了属于用作抗微生物剂或其中间体的碳青霉烯或半胱氨酸衍生物的新型β-内酰胺化合物及其制备方法。
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8.发明申请COCRYSTAL OF PIPERACILLIN SODIUM AND SULBACTAM SODIUM AND PREPARATION METHOD THEREOF, AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF 有权哌醋酸钠和硫酸钠钠的制备方法及其制备方法，以及含有其的药物组合物及其用途公开(公告)号：US20150299222A1
公开(公告)日：2015-10-22
申请号：US14428239
申请日：2012-09-14
发明人： Haiyong WANG , Jing LI
IPC分类号： C07D499/887
CPC分类号： C07D499/887 , A61K31/43 , A61K31/496 , C07D499/00 , C07D499/04 , C07D499/68
摘要： Provided in the present invention are a cocrystal of piperacillin sodium and sulbactam sodium and preparation method thereof, as well as pharmaceutical compositions containing the same and uses thereof in treating infections caused by drug-resistant bacteria, such as a “super bacterium” producing NDM-1 and the like. The cocrystal of piperacillin sodium and sulbactam sodium contains diffraction angles of 14.24°, 16.58°, 16.79°, 17.77°, 19.20°, 20.21°, 20.39°, 23.06°, 27.86° and 32.16° represented by 2θ in an X-ray powder diffraction analysis spectrum.
摘要翻译： 本发明提供了哌拉西林钠和舒巴坦钠的共结晶体及其制备方法，以及含有该组合物的药物组合物及其用于治疗由耐药性细菌引起的感染，如产生NDM-1的“超细菌” 1等。 哌拉西林钠和舒巴坦钠的共结晶体含有由2和代表的14.24°，16.58°，16.79°，17.77°，19.20°，20.21°，20.39°，23.06°，27.86°和32.16°的衍射角; 在X射线粉末衍射分析光谱中。
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9.发明授权Halogenated phenols for diagnostics, antioxidant protection and drug delivery 有权用于诊断，抗氧化保护和药物输送的卤化酚公开(公告)号：US09144613B2
公开(公告)日：2015-09-29
申请号：US14156896
申请日：2014-01-16
申请人： Keith R. Latham
发明人： Keith R. Latham
IPC分类号： A61K49/00 , G01N33/52 , A61K51/04 , A61K49/04 , A61K47/48 , C07C43/295 , C07C217/60 , C07C323/52 , C07C229/36 , C07C233/25 , C07D475/08 , C07D489/02 , C07D499/887 , C07D209/36 , C07J1/00 , C07J5/00
CPC分类号： A61K47/48023 , A61K49/006 , A61K49/0438 , A61K51/0446 , C07C43/295 , C07C217/60 , C07C229/36 , C07C233/25 , C07C323/52 , C07D209/36 , C07D475/08 , C07D489/02 , C07D499/897 , C07J1/0022 , C07J5/0053 , G01N33/52 , Y10T436/145555
摘要： The present invention relates to a composition and method for the detection of a detectable product formed from a compound of the present invention in the body of an individual. The detectable product may include a halide or a benzenetriol-based or benzenetetrol-based product of a dehalogenation reaction in the presence of FROS. In many embodiments, an indigo-like product formed from an indigogenic compound of the present invention may also be a detectable product for diagnostic purposes. This indigo-like product may have a higher residence time in tissues where it is formed, thus providing a detectable product localized to sites of high FROS. An indigogenic compound containing one or more radioactive isotopes is further provided for therapeutic purposes.
摘要翻译： 本发明涉及一种用于检测在个体内由本发明化合物形成的可检测产物的组合物和方法。 可检测的产物可以包括在FROS存在下脱卤反应的卤化物或基于苯三醇或苯并四氢呋喃的产物。 在许多实施方案中，由本发明的靛蓝化合物形成的靛蓝样产物也可以是用于诊断目的的可检测产物。 这种靛蓝样产品可以在其形成的组织中具有更高的停留时间，从而提供定位于高FROS位点的可检测产物。 进一步提供含有一种或多种放射性同位素的靛蓝化合物用于治疗目的。
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公开(公告)号：US07795244B2
公开(公告)日：2010-09-14
申请号：US12164818
申请日：2008-06-30
IPC分类号： C07D499/887 , A61K31/431 , A61P31/04
CPC分类号： C07D499/887
摘要： Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans. This abstract is not limiting to the invention.
摘要翻译： 口服生物可利用的磺脲类前体药物，例如及其溶剂化物和水合物，其制备，其制剂，以及治疗和预防哺乳动物如人类感染的用途。 该摘要不限于本发明。
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