发明授权
- 专利标题: In vitro assessment of cardiovascular events by assay for neo-eptitopes of titin protein
- 专利标题(中): 通过测定滴度蛋白质的新视力来评估心血管事件
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申请号: US14232405申请日: 2012-07-06
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公开(公告)号: US09500659B2公开(公告)日: 2016-11-22
- 发明人: Diana Julie Leeming , Morten Karsdal , Efstathios Vassiliadis
- 申请人: Diana Julie Leeming , Morten Karsdal , Efstathios Vassiliadis
- 申请人地址: DK Herlev
- 专利权人: Nordic Bioscience A/S
- 当前专利权人: Nordic Bioscience A/S
- 当前专利权人地址: DK Herlev
- 代理商 Benjamin Aaron Adler
- 优先权: GB1111788.4 20110711
- 国际申请: PCT/EP2012/063278 WO 20120706
- 国际公布: WO2013/007643 WO 20130117
- 主分类号: G01N31/00
- IPC分类号: G01N31/00 ; G01N33/53 ; G01N33/68 ; C07K16/18 ; C07K14/47 ; G01N33/566
摘要:
An immunoassay for the quantification of fragments having an N- or a C-terminal neo-epitope formed by cleavage of a titin protein by a proteinase is provided. The immunoassay includes the steps of contacting a sample with an antibody specifically binding to the N- or C-terminal neo-epitope of the fragments and determining the level of binding.
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