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公开(公告)号：US09891234B2
公开(公告)日：2018-02-13
申请号：US14116924
申请日：2012-05-04
CPC分类号： G01N33/6893 , C07K14/4725 , C07K16/18 , C07K2317/34 , C12Q1/37 , G01N33/6878 , G01N2800/32 , G01N2800/323
摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of mimecan, a protein of an atherosclerotic plaque, by a proteinase is provided. In the method a sample, such as urine or serum, is contacted with an antibody reactive with the neo-epitope and the level of binding of the antibody to peptide fragments in the sample is determined. The assay is predictive of risk of cardiovascular disease events.
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2.发明授权In vitro assessment of cardiovascular events by assay for neo-eptitopes of titin protein 有权通过测定滴度蛋白质的新视力来评估心血管事件公开(公告)号：US09500659B2
公开(公告)日：2016-11-22
申请号：US14232405
申请日：2012-07-06
CPC分类号： G01N33/6887 , C07K14/4716 , C07K16/18 , C07K2317/34 , G01N33/566 , G01N33/6893 , G01N2333/4712 , G01N2800/32
摘要： An immunoassay for the quantification of fragments having an N- or a C-terminal neo-epitope formed by cleavage of a titin protein by a proteinase is provided. The immunoassay includes the steps of contacting a sample with an antibody specifically binding to the N- or C-terminal neo-epitope of the fragments and determining the level of binding.
摘要翻译： 提供了通过用蛋白酶切割蛋白质所产生的具有N-或C-末端新表位的片段进行定量的免疫测定。 免疫测定包括使样品与特异性结合片段的N-或C-末端新表位的抗体接触并确定结合水平的步骤。
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3.发明申请Pathology indicating measure related to cartilage structure and automatic quantification thereof 有权病理学指标与软骨结构相关的测量及其自动定量公开(公告)号：US20100220907A1
公开(公告)日：2010-09-02
申请号：US12311153
申请日：2007-09-19
申请人： Erik B. Dam , Arish Qazi , Morten Karsdal , Paola C. Petterson , Mads Nielsen , Claus Christiansen
发明人： Erik B. Dam , Arish Qazi , Morten Karsdal , Paola C. Petterson , Mads Nielsen , Claus Christiansen
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/34 , G06K2209/055 , G06T2207/30008
摘要： A method for the analysis of three dimensional scan data representing an articular cartilage is provided to extract a quantitative parameter indicative of joint pathology. A measure representative of cartilage homogeneity is derived from this three dimensional image data. The measured value is compared with similar measured values previously established in respect of healthy joints and/or joints characterised by a pathology.
摘要翻译： 提供了用于分析表示关节软骨的三维扫描数据的方法，以提取指示关节病理学的定量参数。 软骨同质性的代表性度量来源于该三维图像数据。 将测量值与先前在由病理学特征的健康关节和/或关节建立的类似测量值进行比较。
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4.发明申请公开(公告)号：US20060160856A1
公开(公告)日：2006-07-20
申请号：US10526208
申请日：2003-09-04
申请人： Bjarne Dahl , Palle Christophersen , Michael En G Sig , Morten Karsdal , Niels Foged , Flemming Jensen
发明人： Bjarne Dahl , Palle Christophersen , Michael En G Sig , Morten Karsdal , Niels Foged , Flemming Jensen
IPC分类号： A61K31/454 , A61K31/41 , C07D403/02
CPC分类号： C07D213/75 , C07C275/26 , C07C275/30 , C07C275/42 , C07C2601/14 , C07D207/16 , C07D209/40 , C07D213/81 , C07D231/40 , C07D257/04 , C07D277/48 , C07D295/192 , C07D307/68 , C07D333/36 , C07D401/12 , C07F9/383 , C07F9/3834 , C07F9/3882 , C07F9/58
摘要： The present invention relates to novel diarylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases responsive to modulation of the mast cell or basophil activity, diseases responsive to inhibition of angiogenesis, or sickle cell anaemia, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作氯化物通道阻断剂的新型二芳基脲衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途，例如用于治疗骨代谢疾病，对调节肥大细胞或嗜碱性粒细胞活性有响应的疾病，对抑制血管生成有反应的疾病或镰状细胞 贫血，以及包含本发明化合物的药物组合物。
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公开(公告)号：US10267809B2
公开(公告)日：2019-04-23
申请号：US15173852
申请日：2016-06-06
IPC分类号： G01N31/00 , G01N33/53 , G01N33/68 , C07K14/775 , C12Q1/37 , G01N33/542 , C07K14/77 , C07K14/78 , G01N33/577
摘要： Provided is a method of bioassay for the quantification of N- or C-terminal neo-epitope biomarkers formed by cleavage of a CRP, ApoE, lumican, versican, perlecan, decorin, biglycan or elastin by a proteinase. The method includes contacting a biofluid sample with an antibody reactive with the neo-epitope biomarker and determining the level of binding of the antibody to the biomarker in the sample. The assay is predictive of risk of cardiovascular disease events.
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公开(公告)号：US09359633B2
公开(公告)日：2016-06-07
申请号：US12740648
申请日：2008-11-04
申请人： Morten Karsdal , Per Qvist , Natasha Barascuk
发明人： Morten Karsdal , Per Qvist , Natasha Barascuk
IPC分类号： G01N31/00 , G01N33/53 , C12Q1/37 , C07K14/775 , G01N33/542
CPC分类号： G01N33/6878 , C07K14/77 , C07K14/775 , C07K14/78 , C12Q1/37 , G01N33/542 , G01N33/577 , G01N33/6893 , G01N2800/32 , G01N2800/50 , G01N2800/52
摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as lumican, versican, perlecan, decorin, biglycan, collagen type III, CRP, ApoE, or elastin, by a proteinase, said comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.
摘要翻译： 一种用于定量肽片段的生物测定方法，其包含通过切割动脉粥样硬化斑块的蛋白质如lumican，versican，perlecan，核心蛋白聚糖，双糖链蛋白聚糖，III型胶原，CRP，ApoE或弹性蛋白的蛋白质形成的新表位。 所述方法包括使诸如尿液或血清的样品与抗原表位反应的抗体接触并确定所述免疫结合配偶体与所述样品中肽片段的结合水平。 该测定法预测心血管疾病事件的风险。
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公开(公告)号：US20150064726A1
公开(公告)日：2015-03-05
申请号：US14130927
申请日：2012-07-04
CPC分类号： G01N33/6896 , C07K14/4711 , C07K16/18 , C07K2317/32 , C07K2317/33 , C07K2317/34 , C12Q1/37 , G01N2333/47 , G01N2333/96486 , G01N2800/2821 , G01N2800/56
摘要： A method of bioassay for the quantification of peptide fragments relevant to neurodegenerative conditions comprising a neo-epitope formed by cleavage of a Tau protein by a secretase such as ADAM10 comprises contacting a blood derived sample with an antibody specific for the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. Neo-epitope containing peptide levels are found to be inversely correlated to cognitive function.
摘要翻译： 用于量化与神经变性病症相关的肽片段的生物测定方法包括通过分泌酶如ADAM10切割Tau蛋白而形成的新表位，包括使血液衍生的样品与新表位特异的抗体接触，并确定 所述免疫结合配偶体与所述样品中肽片段的结合水平。 发现含有多肽水平的新表位与认知功能成反比。
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8.发明授权Pathology indicating measure related to cartilage structure and automatic quantification thereof 有权病理学指标与软骨结构相关的测量及其自动定量公开(公告)号：US08300910B2
公开(公告)日：2012-10-30
申请号：US12311153
申请日：2007-09-19
申请人： Erik B. Dam , Arish Qazi , Morten Karsdal , Paola C. Petterson , Mads Nielsen , Claus Christiansen
发明人： Erik B. Dam , Arish Qazi , Morten Karsdal , Paola C. Petterson , Mads Nielsen , Claus Christiansen
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/34 , G06K2209/055 , G06T2207/30008
摘要： A method for the analysis of three dimensional scan data representing an articular cartilage is provided to extract a quantitative parameter indicative of joint pathology. A measure representative of cartilage homogeneity is derived from this three dimensional image data. The measured value is compared with similar measured values previously established in respect of healthy joints and/or joints characterised by a pathology.
摘要翻译： 提供了用于分析表示关节软骨的三维扫描数据的方法，以提取指示关节病理学的定量参数。 软骨同质性的代表性度量来源于该三维图像数据。 将测量值与先前在由病理学特征的健康关节和/或关节建立的类似测量值进行比较。
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公开(公告)号：US20100323377A1
公开(公告)日：2010-12-23
申请号：US12740648
申请日：2008-11-04
申请人： Morten Karsdal , Per Qvist , Natasha Barascuk
发明人： Morten Karsdal , Per Qvist , Natasha Barascuk
IPC分类号： G01N33/68 , G01N33/566 , C07K16/18 , C07K7/06 , C12N5/07 , C12N15/63 , C07H21/00 , C07K7/08 , C12N5/10
CPC分类号： G01N33/6878 , C07K14/77 , C07K14/775 , C07K14/78 , C12Q1/37 , G01N33/542 , G01N33/577 , G01N33/6893 , G01N2800/32 , G01N2800/50 , G01N2800/52
摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as lumican, versican, perlecan, decorin, biglycan, collagen type III, CRP, ApoE, or elastin, by a proteinase, said comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.
摘要翻译： 一种用于定量肽片段的生物测定方法，其包含通过切割动脉粥样硬化斑块的蛋白质如lumican，versican，perlecan，核心蛋白聚糖，双糖链蛋白聚糖，III型胶原，CRP，ApoE或弹性蛋白的蛋白质形成的新表位。 所述方法包括使诸如尿液或血清的样品与抗原表位反应的抗体接触并确定所述免疫结合配偶体与所述样品中肽片段的结合水平。 该测定法预测心血管疾病事件的风险。
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公开(公告)号：US09835631B2
公开(公告)日：2017-12-05
申请号：US15014241
申请日：2016-02-03
申请人： Federica Genovese , Mette Juul Nielsen , Lise Larsen , Diana Julie Oersnes-Leeming , Morten Karsdal
发明人： Federica Genovese , Mette Juul Nielsen , Lise Larsen , Diana Julie Oersnes-Leeming , Morten Karsdal
IPC分类号： G01N33/53 , G01N33/68 , G01N33/577
CPC分类号： G01N33/6893 , G01N33/577 , G01N2333/78 , G01N2800/085 , G01N2800/52 , G01N2800/7052
摘要： Provided herein is a sandwich immunoassay for detecting cross-linked PIIINP that has at least two strands of PIIINP joined together by inter-strand cross-linking each having a C-terminal neo-epitope of PIIINP that is generated by N-protease cleavage of intact type III procollagen. A biological sample having the cross-linked PIIINP is contacted with a first surface-bound monoclonal antibody and then by a second monoclonal antibody, both specifically reactive with a neoepitope in the C-terminal sequence of PIIINP, and then binding of the second monoclonal antibody is determined. Also provided is a method for evaluating the efficacy of an antagonist drug targeting lysyl oxidases via the immunoassay and a kit containing a solid support binding the first monoclonal antibody and containing the second monoclonal antibody.
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