Biochemical markers for CVD risk assessment
    6.
    发明授权
    Biochemical markers for CVD risk assessment 有权
    CVD风险评估的生化标志物

    公开(公告)号:US09359633B2

    公开(公告)日:2016-06-07

    申请号:US12740648

    申请日:2008-11-04

    摘要: A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as lumican, versican, perlecan, decorin, biglycan, collagen type III, CRP, ApoE, or elastin, by a proteinase, said comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

    摘要翻译: 一种用于定量肽片段的生物测定方法,其包含通过切割动脉粥样硬化斑块的蛋白质如lumican,versican,perlecan,核心蛋白聚糖,双糖链蛋白聚糖,III型胶原,CRP,ApoE或弹性蛋白的蛋白质形成的新表位。 所述方法包括使诸如尿液或血清的样品与抗原表位反应的抗体接触并确定所述免疫结合配偶体与所述样品中肽片段的结合水平。 该测定法预测心血管疾病事件的风险。