- Patent Title: Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen
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Application No.: US14549685Application Date: 2014-11-21
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Publication No.: US09512213B2Publication Date: 2016-12-06
- Inventor: Roderick A. Hyde , Wayne R. Kindsvogel
- Applicant: Elwha LLC
- Applicant Address: US WA Bellevue
- Assignee: Elwha LLC
- Current Assignee: Elwha LLC
- Current Assignee Address: US WA Bellevue
- Main IPC: A61K35/12
- IPC: A61K35/12 ; A01N63/00 ; C07K16/18 ; A61K39/00 ; C12N5/0781 ; C07K16/00 ; C07K16/10 ; C07K16/12 ; C07K16/30 ; C07K16/44 ; G01N33/68
Abstract:
Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen.
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