发明授权
US09518058B2 Process for the preparation of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide
有权
制备N,N-二环丙基-4-(1,5-二甲基-1H-吡唑-3-基氨基)-6-乙基-1-甲基-1,6-二氢咪唑并[4,5-d]吡咯的方法 [2,3-b]吡啶-7-甲酰胺
- 专利标题: Process for the preparation of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide
- 专利标题(中): 制备N,N-二环丙基-4-(1,5-二甲基-1H-吡唑-3-基氨基)-6-乙基-1-甲基-1,6-二氢咪唑并[4,5-d]吡咯的方法 [2,3-b]吡啶-7-甲酰胺
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申请号: US14914330申请日: 2014-08-28
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公开(公告)号: US09518058B2公开(公告)日: 2016-12-13
- 发明人: Martin D. Eastgate , Gregory L. Beutner , Benjamin Cohen , Nicolas Cuniere , Lopa V. Desai , Monica Fitzgerald , Qi Gao , Michael Bryan Hay , Michael Joseph Lawler , Paul C. Lobben , Christopher S. Regens , Thorsten Rosner , Neil Strotman , Carolyn S. Wei , Yi Xiao , Bin Zheng , Keming Zhu
- 申请人: BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: US NJ Princeton
- 代理商 Elliott Korsen
- 国际申请: PCT/US2014/053054 WO 20140828
- 国际公布: WO2015/031562 WO 20150305
- 主分类号: C07D471/14
- IPC分类号: C07D471/14 ; C07D207/42 ; C07D403/04 ; C07D231/16
摘要:
The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.
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