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![PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE](/abs-image/US/2016/08/11/US20160229854A1/abs.jpg.150x150.jpg)
1.发明申请PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE 审中-公开制备N，N-二异丙基-4-（1,5-二甲基-1H-吡唑-3-基氨基）-6-乙基-1-甲基-1,6-二氢吲哚并[4,5-d]吡咯的方法 [2,3-b]吡啶-7-羧酰胺公开(公告)号：US20160229854A1
公开(公告)日：2016-08-11
申请号：US14914330
申请日：2014-08-28
发明人： Martin D. Eastgate , Gregory L. Beutner , Benjamin Cohen , Nicolas Cuniere , Lopa V. Desai , Monica Fitzgerald , Qi Gao , Michael Bryan Hay , Michael Joseph Lawler , Paul C. Lobben , Christopher S. Regens , Thorsten Rosner , Neil Strotman , Carolyn S. Wei , Yi Xiao , Bin Zheng , Keming Zhu
IPC分类号： C07D471/14 , C07D403/04 , C07D231/16 , C07D207/42
CPC分类号： C07D471/14 , C07D207/42 , C07D231/16 , C07D403/04
摘要： The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.
摘要翻译： 本发明涉及一种合成N，N-二环丙基-4-（1,5-二甲基-1H-吡唑-3-基氨基）-6-乙基-1-甲基-1,6-二氢咪唑并[4,5 d]吡咯并[2,3-b]吡啶-7-甲酰胺，其化学式（I）化合物（I）目前正在临床试验中用于治疗骨髓增生性疾病，如多发性红血球病，血小板减少症和原发性骨髓纤维化。
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![Process for the preparation of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide](/abs-image/US/2016/12/13/US09518058B2/abs.jpg.150x150.jpg)
2.发明授权Process for the preparation of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide 有权制备N，N-二环丙基-4-（1,5-二甲基-1H-吡唑-3-基氨基）-6-乙基-1-甲基-1,6-二氢咪唑并[4,5-d]吡咯的方法 [2,3-b]吡啶-7-甲酰胺公开(公告)号：US09518058B2
公开(公告)日：2016-12-13
申请号：US14914330
申请日：2014-08-28
发明人： Martin D. Eastgate , Gregory L. Beutner , Benjamin Cohen , Nicolas Cuniere , Lopa V. Desai , Monica Fitzgerald , Qi Gao , Michael Bryan Hay , Michael Joseph Lawler , Paul C. Lobben , Christopher S. Regens , Thorsten Rosner , Neil Strotman , Carolyn S. Wei , Yi Xiao , Bin Zheng , Keming Zhu
IPC分类号： C07D471/14 , C07D207/42 , C07D403/04 , C07D231/16
CPC分类号： C07D471/14 , C07D207/42 , C07D231/16 , C07D403/04
摘要： The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.
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