Invention Grant
US09555007B2 Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
有权
用于包封细胞和细胞聚集体的多层水凝胶胶囊
- Patent Title: Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
- Patent Title (中): 用于包封细胞和细胞聚集体的多层水凝胶胶囊
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Application No.: US13831250Application Date: 2013-03-14
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Publication No.: US09555007B2Publication Date: 2017-01-31
- Inventor: Minglin Ma , Daniel G. Anderson , Robert S. Langer , Omid Veiseh , Arturo Jose Vegas , Joshua Charles Doloff , Delai Chen , Christian J. Kastrup
- Applicant: The Children's Medical Center Corporation , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Applicant Address: US MA Cambridge US MA Boston
- Assignee: Massachusetts Institute of Technology,The Children's Medical Center Corporation
- Current Assignee: Massachusetts Institute of Technology,The Children's Medical Center Corporation
- Current Assignee Address: US MA Cambridge US MA Boston
- Agency: Pabst Patent Group LLP
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K9/50 ; A61K35/39 ; A61K35/12
Abstract:
Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
Public/Granted literature
- US20140271843A1 Multi-Layer Hydrogel Capsules for Encapsulation of Cells and Cell Aggregates Public/Granted day:2014-09-18
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