发明授权
- 专利标题： N-cyanomethylamides as inhibitors of janus kinase
- 专利标题（中）： N-氰甲基酰胺作为甘蔗激酶的抑制剂
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申请号： US14910028申请日： 2014-08-06
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公开(公告)号： US09556148B2公开(公告)日： 2017-01-31
- 发明人: Ranjit Desai , Jigar Desai , Pankaj Patel
- 申请人： CADILA HEALTHCARE LIMITED
- 申请人地址： IN Ahmedabad
- 专利权人： Cadila Healthcare Limited
- 当前专利权人： Cadila Healthcare Limited
- 当前专利权人地址： IN Ahmedabad
- 代理机构： Ladas & Parry LLP
- 优先权： IN2611/MUM/2013 20130807
- 国际申请： PCT/IN2014/000515 WO 20140806
- 国际公布： WO2015/019365 WO 20150212
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D417/14 ; C07D413/14 ; C07D403/14 ; C07D409/10 ; C07D409/14 ; C07D498/08 ; C07D513/08 ; C07D401/12 ; C07D403/12 ; C07D405/14 ; C07D407/12 ; C07D407/14 ; C07D409/12 ; C07D471/08 ; C07D491/056 ; C07D491/08 ; C07D491/107 ; C07D495/08
摘要：
The present invention relates to compounds of general formula (1) that are inhibitors of Janus Kinase (JAK), a family of tyrosine kinases that are involved in inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons. In particular, the compound of the invention inhibits JAK1 and/or JAK2 and/or JAK3 sub families. The present invention also provides methods for the production of the compounds of the invention, pharmaceutical compositions comprising the compounds of the invention, their tautomeric forms, and their pharmaceutically acceptable salts
公开/授权文献
- US20160176849A1 N-CYANOMETHYLAMIDES AS INHIBITORS OF JANUS KINASE 公开/授权日：2016-06-23
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