- 专利标题： Polyene compound, method for preparing the same, and antifungal drug comprising novel polyene compound as active ingredient
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申请号： US14369869申请日： 2012-08-31
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公开(公告)号： US09605015B2公开(公告)日： 2017-03-28
- 发明人: Eung-Soo Kim , Kyu Boem Han , Shuangjun Lin , Dekun Kong , Linquan Bai , Zixin Deng , David H. Sherman , Mi-Jin Lee
- 申请人： Eung-Soo Kim , Kyu Boem Han , Shuangjun Lin , Dekun Kong , Linquan Bai , Zixin Deng , David H. Sherman , Mi-Jin Lee
- 申请人地址： KR Incheon
- 专利权人： INHA-INDUSTRY PARTNERSHIP INSTITUTE
- 当前专利权人： INHA-INDUSTRY PARTNERSHIP INSTITUTE
- 当前专利权人地址： KR Incheon
- 代理机构： Schwegman Lundberg & Woessner, P.A.
- 优先权： KR10-2011-0147050 20111230
- 国际申请： PCT/KR2012/007000 WO 20120831
- 国际公布： WO2013/100315 WO 20130704
- 主分类号： C07H15/26
- IPC分类号： C07H15/26 ; C12P19/62 ; C07H17/08 ; C07D493/08
摘要：
The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel polyene compound as an active ingredient. Compared to nystatin comprising one sugar, NNP, which is the polyene compound similar to nystatin, displays 300 times higher solubility and ten times lower cytotoxicity while maintaining antifungal activity, and thus can be useful in developing a novel polyene antifungal agent having improved solubility and less toxicity in terms of pharmacokinetics.
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