An analog frontend (AFE) interface is dynamically programmable. A single AFE circuit can interface with multiple different analog devices, and dynamically configure its input for efficient interfacing with each different analog device. The AFE receives multiple unprocessed analog input signals and samples the analog input signals. A preprocessor element in the AFE analyzes the input signals and generates control signals based on the analyzing. The control signals dynamically adjust how the AFE samples the analog input signals, and can improve the efficiency of the operation the AFE.