Embodiments herein provide for In-Flight Entertainment (IFE) content distribution onboard an aircraft to Personal Electronic Devices (PEDs) of passengers over Universal Serial Bus (USB). One embodiment comprises system that includes a media server disposed within the aircraft. The media server provides IFE content streams to the PEDs of passengers. The system further includes an Ethernet network that is electrically coupled to the media server, and a plurality of IFE distribution units that are disposed within the aircraft. At least one of the IFE distribution units includes an Ethernet interface that is electrically coupled to the Ethernet network, a USB port located proximate to a seat within the aircraft, and a controller. The controller is electrically coupled to the Ethernet interface and the USB port, and converts the IFE content streams from the media server from Ethernet frames to USB frames for presentation to the PEDs.