Invention Grant
- Patent Title: Mutated immunoglobulin-binding polypeptides
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Application No.: US14904077Application Date: 2014-07-10
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Publication No.: US09663558B2Publication Date: 2017-05-30
- Inventor: Mats Ander , Goran Bauren , Tomas Bjorkman , Gustav Rodrigo
- Applicant: GE Healthcare Bio-Sciences AB
- Applicant Address: SE Uppsala
- Assignee: GE Healthcare Bio-Sciences AB
- Current Assignee: GE Healthcare Bio-Sciences AB
- Current Assignee Address: SE Uppsala
- Agency: Wood IP LLC
- Priority: SE1350859 20130710; SE1350860 20130710
- International Application: PCT/SE2014/050882 WO 20140710
- International Announcement: WO2015/005862 WO 20150115
- Main IPC: C07K14/31
- IPC: C07K14/31 ; C07K1/22 ; B01D15/38 ; B01J20/286 ; B01J20/32 ; C07K14/745 ; C07K16/00
Abstract:
A polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A, as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 15 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of the polypeptide, as well as separation matrices comprising the multimers or polypeptides.
Public/Granted literature
- US20160207966A1 MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES Public/Granted day:2016-07-21
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