发明授权
- 专利标题: Prophylactic and/or therapeutic agent for functional gastrointestinal disorders
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申请号: US12523010申请日: 2008-01-17
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公开(公告)号: US09675647B2公开(公告)日: 2017-06-13
- 发明人: Masayuki Uchida , Shigeru Yamato , Hajime Ariga , Hirotsugu Uehara , Tomofumi Amano , Keiko Morikubo , Kaori Yoshida
- 申请人: Masayuki Uchida , Shigeru Yamato , Hajime Ariga , Hirotsugu Uehara , Tomofumi Amano , Keiko Morikubo , Kaori Yoshida
- 申请人地址: JP Tokyo
- 专利权人: MEIJI CO., LTD.
- 当前专利权人: MEIJI CO., LTD.
- 当前专利权人地址: JP Tokyo
- 代理机构: Saliwanchik, Lloyd & Eisenschenk
- 优先权: JP2007-007628 20070117
- 国际申请: PCT/JP2008/050515 WO 20080117
- 国际公布: WO2008/088008 WO 20080724
- 主分类号: A61K35/74
- IPC分类号: A61K35/74
摘要:
The present inventors conducted dedicated studies, and as a result discovered that propionic acid bacteria fermentation products have a preventive/therapeutic effect on functional gastrointestinal disorders in in vitro tests and tests using patients with irritable bowel syndrome, and completed the present invention. Specifically, the present inventors discovered, in in vitro tests, that the products have an effect of increasing the intestinal contraction frequency without changing the intestinal contractile force in a distal colon-specific manner. Moreover, effects of improving the defecation condition, general abdominal condition, and health-related QOL in patients with irritable bowel syndrome were also found. Furthermore, propionic acid bacteria fermentation products can be taken in large amounts. Therefore, the propionic acid bacteria fermentation products can be expected to have an effect of preventing/treating functional gastrointestinal disorders safely.
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