公开(公告)号：US09675647B2

公开(公告)日：2017-06-13

申请号：US12523010

申请日：2008-01-17

申请人： Masayuki Uchida ,  Shigeru Yamato ,  Hajime Ariga ,  Hirotsugu Uehara ,  Tomofumi Amano ,  Keiko Morikubo ,  Kaori Yoshida

发明人： Masayuki Uchida ,  Shigeru Yamato ,  Hajime Ariga ,  Hirotsugu Uehara ,  Tomofumi Amano ,  Keiko Morikubo ,  Kaori Yoshida

IPC分类号： A61K35/74

CPC分类号： A61K35/74

摘要： The present inventors conducted dedicated studies, and as a result discovered that propionic acid bacteria fermentation products have a preventive/therapeutic effect on functional gastrointestinal disorders in in vitro tests and tests using patients with irritable bowel syndrome, and completed the present invention. Specifically, the present inventors discovered, in in vitro tests, that the products have an effect of increasing the intestinal contraction frequency without changing the intestinal contractile force in a distal colon-specific manner. Moreover, effects of improving the defecation condition, general abdominal condition, and health-related QOL in patients with irritable bowel syndrome were also found. Furthermore, propionic acid bacteria fermentation products can be taken in large amounts. Therefore, the propionic acid bacteria fermentation products can be expected to have an effect of preventing/treating functional gastrointestinal disorders safely.

公开(公告)号：US20100040698A1

公开(公告)日：2010-02-18

申请号：US12523010

申请日：2008-01-17

申请人： Masayuki Uchida ,  Shigeru Yamato ,  Hajime Ariga ,  Hirotsugu Uehara ,  Tomofumi Amano ,  Keiko Morikubo ,  Kaori Yoshida

发明人： Masayuki Uchida ,  Shigeru Yamato ,  Hajime Ariga ,  Hirotsugu Uehara ,  Tomofumi Amano ,  Keiko Morikubo ,  Kaori Yoshida

IPC分类号： A61K35/20 ,  A61P1/00

CPC分类号： A61K35/74

摘要： The present inventors conducted dedicated studies, and as a result discovered that propionic acid bacteria fermentation products have a preventive/therapeutic effect on functional gastrointestinal disorders in in vitro tests and tests using patients with irritable bowel syndrome, and completed the present invention. Specifically, the present inventors discovered, in in vitro tests, that the products have an effect of increasing the intestinal contraction frequency without changing the intestinal contractile force in a distal colon-specific manner. Moreover, effects of improving the defecation condition, general abdominal condition, and health-related QOL in patients with irritable bowel syndrome were also found. Furthermore, propionic acid bacteria fermentation products can be taken in large amounts. Therefore, the propionic acid bacteria fermentation products can be expected to have an effect of preventing/treating functional gastrointestinal disorders safely.

摘要翻译： 本发明人进行了专门研究，结果发现丙酸菌发酵产品在使用肠易激综合征患者的体外试验和试验中对功能性胃肠疾病具有预防/治疗作用，并完成了本发明。 具体地说，本发明人在体外试验中发现，在远端结肠特异性地改变肠收缩力的情况下，该产品具有增加肠收缩频率的作用。 此外，还发现改善肠易激综合征患者的排便条件，一般腹部状况和健康相关生活质量的影响。 此外，可以大量摄取丙酸菌发酵产物。 因此，丙酸菌发酵产物可以预期具有安全地预防/治疗功能性胃肠道疾病的作用。