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    PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
    2.
    发明申请
    PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR FUNCTIONAL GASTROINTESTINAL DISORDERS 有权
    功能性胃肠疾病的预防和/或治疗药物

    公开(公告)号：US20100040698A1

    公开(公告)日：2010-02-18

    申请号：US12523010

    申请日：2008-01-17

    申请人： Masayuki Uchida ,  Shigeru Yamato ,  Hajime Ariga ,  Hirotsugu Uehara ,  Tomofumi Amano ,  Keiko Morikubo ,  Kaori Yoshida

    发明人： Masayuki Uchida ,  Shigeru Yamato ,  Hajime Ariga ,  Hirotsugu Uehara ,  Tomofumi Amano ,  Keiko Morikubo ,  Kaori Yoshida

    IPC分类号： A61K35/20 ,  A61P1/00

    CPC分类号： A61K35/74

    摘要： The present inventors conducted dedicated studies, and as a result discovered that propionic acid bacteria fermentation products have a preventive/therapeutic effect on functional gastrointestinal disorders in in vitro tests and tests using patients with irritable bowel syndrome, and completed the present invention. Specifically, the present inventors discovered, in in vitro tests, that the products have an effect of increasing the intestinal contraction frequency without changing the intestinal contractile force in a distal colon-specific manner. Moreover, effects of improving the defecation condition, general abdominal condition, and health-related QOL in patients with irritable bowel syndrome were also found. Furthermore, propionic acid bacteria fermentation products can be taken in large amounts. Therefore, the propionic acid bacteria fermentation products can be expected to have an effect of preventing/treating functional gastrointestinal disorders safely.

    摘要翻译： 本发明人进行了专门研究，结果发现丙酸菌发酵产品在使用肠易激综合征患者的体外试验和试验中对功能性胃肠疾病具有预防/治疗作用，并完成了本发明。 具体地说，本发明人在体外试验中发现，在远端结肠特异性地改变肠收缩力的情况下，该产品具有增加肠收缩频率的作用。 此外，还发现改善肠易激综合征患者的排便条件，一般腹部状况和健康相关生活质量的影响。 此外，可以大量摄取丙酸菌发酵产物。 因此，丙酸菌发酵产物可以预期具有安全地预防/治疗功能性胃肠道疾病的作用。

    Method for direct-electroplating an electrically nonconductive substrate
    4.
    发明授权
    Method for direct-electroplating an electrically nonconductive substrate 失效
    直接电镀不导电基板的方法

    公开(公告)号：US5616230A

    公开(公告)日：1997-04-01

    申请号：US374576

    申请日：1995-01-20

    申请人： Kuniaki Otsuka ,  Kazue Yamamoto ,  Satoshi Konishi ,  Shigeru Yamato

    发明人： Kuniaki Otsuka ,  Kazue Yamamoto ,  Satoshi Konishi ,  Shigeru Yamato

    IPC分类号： C25D5/54 ,  H05K3/18 ,  H05K3/42 ,  C25D5/02 ,  C25D5/34 ,  C25D5/56

    CPC分类号： C25D5/54 ,  H05K3/424

    摘要： A process for plating an electrically nonconductive substrate by the following sequence of steps:(1) a step of treating an electrically nonconductive substrate with a solution containing a silane coupling agent;(2) a step of treating the electrically nonconductive substrate from said step (1) with a solution containing an anionic surfactant;(3) a step of the electrically nonconductive substrate from said step (2) with a solution containing a palladium compound and at least one nitrogen-containing sulfur compound selected from among thiourea and its derivatives;(4) a step of treating the electrically nonconductive substrate from said step (3) with a reducing solution containing at least one member selected from among sodium borohydride, sodium hypophosphite, hydrazine, dimethylaminoborane, hydroxylamine and glyoxylic acid; and(5) a step of forming an electroplating layer on the electrically nonconductive substrate from said step (4).With this process, improved productivity is obtained through process simplification, reduced treating time and improved working environment.

    摘要翻译： PCT No.PCT / JP94 / 00826 Sec。 371日期1995年1月24日 102（e）日期1995年1月24日PCT 1994年5月24日提交PCT通过以下步骤电镀不导电基材的方法：（1）用含有硅烷偶联剂的溶液处理非导电性基材的工序; （2）用含有阴离子表面活性剂的溶液从所述工序（1）处理非导电性基材的工序; （3）使用含有钯化合物和至少一种选自硫脲及其衍生物的含氮硫化合物的溶液，从所述步骤（2）获得不导电基质的步骤; （4）从含有选自硼氢化钠，次磷酸钠，肼，二甲基氨基硼烷，羟胺和乙醛酸中的至少一种的还原溶液处理所述工序（3）的非导电性基材的工序; 和（5）从所述步骤（4）在所述不导电基材上形成电镀层的步骤。 通过这个过程，通过简化过程，缩短处理时间和改善工作环境，可以获得提高的生产率。