Invention Grant
- Patent Title: Benzodiazepine dimers, conjugates thereof, and methods of making and using
-
Application No.: US15351843Application Date: 2016-11-15
-
Publication No.: US09676794B2Publication Date: 2017-06-13
- Inventor: Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00
Abstract:
Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
Public/Granted literature
- US20170073357A1 BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING Public/Granted day:2017-03-16
Information query
