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公开(公告)号：US10053454B2
公开(公告)日：2018-08-21
申请号：US14770230
申请日：2014-02-27
发明人： Michael A. Poss , David R. Tortolani , Ashok Vinayak Purandare , John S. Tokarski , Christopher P. Mussari , Muthoni G. Kamau , Dharmpal S. Dodd , Ashvinikumar V. Gavai , Daniel O'Malley , Tram N. Huynh , Wayne Vaccaro , Lalgudi S. Harikrishnan
IPC分类号： C07D413/04 , C07D413/10 , C07D413/14 , C07D417/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553
CPC分类号： C07D413/10 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20160108050A1
公开(公告)日：2016-04-21
申请号：US14976476
申请日：2015-12-21
发明人： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer lnghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC分类号： C07D487/04 , C07F9/6561 , C07F7/18 , C07D519/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US10112975B2
公开(公告)日：2018-10-30
申请号：US15785675
申请日：2017-10-17
发明人： Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
IPC分类号： C07D487/04 , C07D519/00 , C07K5/062
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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公开(公告)号：US10450318B2
公开(公告)日：2019-10-22
申请号：US15776936
申请日：2016-12-14
IPC分类号： C07D487/04 , A61P35/00 , C07D519/00
摘要： The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications.
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公开(公告)号：US09676794B2
公开(公告)日：2017-06-13
申请号：US15351843
申请日：2016-11-15
发明人： Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
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6.发明授权Benzodiazepine dimers, conjugates thereof, and methods of making and using 有权苯并二氮杂二聚体，其偶联物，以及制备和使用方法公开(公告)号：US09527871B2
公开(公告)日：2016-12-27
申请号：US14994296
申请日：2016-01-13
发明人： Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
IPC分类号： C07D487/04 , C07D519/00 , A61K47/48 , C07K16/18 , C07K16/28 , C07K16/30
CPC分类号： C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
摘要翻译： 具有由其中R1表示的结构的苯并二氮杂二聚体，其中式（I），（Ia）和（Ib）中的变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
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7.发明申请公开(公告)号：US20160200742A1
公开(公告)日：2016-07-14
申请号：US14994296
申请日：2016-01-13
发明人： Yong Zhang , Ivar M. McDonald , Naidu S. Chowdari , Tram N. Huynh , Robert M. Borzilleri , Sanjeev Gangwar
IPC分类号： C07D519/00 , A61K47/48 , C07K16/28 , C07K16/18 , C07K16/30
CPC分类号： C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
摘要： Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
摘要翻译： 具有由其中R1表示的结构的苯并二氮杂二聚体，其中式（I），（Ia）和（Ib）中的变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
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公开(公告)号：US20160009701A1
公开(公告)日：2016-01-14
申请号：US14770230
申请日：2014-02-27
发明人： Michael A. Poss , David R. Tortolani , Ashok Vinayak Purandare , John S. Tokarski , Christopher P. Mussari , Muthoni G. Kamau , Dharmpal S. Dodd , Ashvinikumar V. Gavai , Daniel O'Malley , Tram N. Huynh , Wayne Vaccaro , Lalgudi S. Harikrishnan
IPC分类号： C07D413/10 , A61K31/5377 , C07D413/14 , A61K31/422 , A61K31/5355 , A61K31/553 , C07D417/14 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/541
CPC分类号： C07D413/10 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及咔唑化合物，包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20150210697A1
公开(公告)日：2015-07-30
申请号：US14414152
申请日：2013-07-12
发明人： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC分类号： C07D487/04 , C07F7/18 , C07D487/10 , C07D487/08 , C07D471/10
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US08940736B2
公开(公告)日：2015-01-27
申请号：US13940619
申请日：2013-07-12
发明人： Ashok Vinayak Purandare , Brian E. Fink , Ashvinikumar V. Gavai , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann
IPC分类号： A61K31/535 , A01N43/00 , A61K31/00 , A01N57/00 , A61K31/675 , C07D413/00 , C07D487/00 , C07D243/08 , A61K31/53 , A61K45/06 , A61K31/5377 , C07D471/10 , C07D487/10 , C07D498/04 , A61K31/551 , C07D487/04 , A61K31/5383 , C07F9/6521
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑三嗪抑制蛋白激酶活性，从而使它们用作抗癌剂。
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