Invention Grant
- Patent Title: Cyclohexyl sulfone RORγ modulators
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Application No.: US15109733Application Date: 2015-01-05
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Publication No.: US09708253B2Publication Date: 2017-07-18
- Inventor: Jingwu Duan , T. G. Murali Dhar , Bin Jiang , Ananta Karmakar , Arun Kumar Gupta , Zhonghui Lu , Carolyn A. Weigelt
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- International Application: PCT/US2015/010084 WO 20150105
- International Announcement: WO2015/103507 WO 20150709
- Main IPC: C07C317/20
- IPC: C07C317/20 ; C07C317/24 ; C07C317/30 ; C07D205/04 ; C07D207/27 ; C07D211/46 ; C07D211/78 ; C07D213/30 ; C07D231/12 ; C07D213/81 ; C07D213/82 ; C07D309/08 ; C07D231/14 ; C07D231/56 ; C07D401/04 ; C07D403/04 ; C07D237/08 ; C07D237/20 ; C07D237/24 ; C07D405/04 ; C07D239/28 ; C07C317/46 ; C07D241/24 ; C07D249/04 ; C07D471/04 ; C07D207/277 ; C07D277/60 ; C07D295/096 ; C07D211/48 ; C07D211/62 ; C07D295/185 ; C07D213/56 ; C07D213/71 ; C07D213/75 ; C07D309/04 ; C07D335/02 ; C07D401/06 ; C07D401/12 ; C07D295/205 ; C07D213/40 ; C07D231/54 ; C07D237/22 ; C07D249/06 ; C07D277/82 ; C07D295/16 ; C07D295/195

Abstract:
Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
Public/Granted literature
- US20160326104A1 CYCLOHEXYL SULFONE ROR GAMMA MODULATORS Public/Granted day:2016-11-10
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