Invention Grant
- Patent Title: Reactive labelling compounds and uses thereof
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Application No.: US14698660Application Date: 2015-04-28
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Publication No.: US09759726B2Publication Date: 2017-09-12
- Inventor: Chi-Huey Wong , Jim-Min Fang , Jiun-Jie Shie
- Applicant: Academia Sinica
- Applicant Address: TW Taipei
- Assignee: ACADEMIA SINICA
- Current Assignee: ACADEMIA SINICA
- Current Assignee Address: TW Taipei
- Agency: Duane Morris LLP
- Main IPC: C07D309/14
- IPC: C07D309/14 ; G01N33/58 ; C07K7/08 ; G01N21/64 ; C07D311/02 ; C07F5/02

Abstract:
Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
Public/Granted literature
- US20150309041A1 REACTIVE LABELLING COMPOUNDS AND USES THEREOF Public/Granted day:2015-10-29
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