- 专利标题： Activation of bioluminescence by structural complementation
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申请号： US14209610申请日： 2014-03-13
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公开(公告)号： US09797890B2公开(公告)日： 2017-10-24
- 发明人: Andrew S. Dixon , Lance Encell , Mary Hall , Keith Wood , Monika Wood , Marie Schwinn , Brock F. Binkowski , Hicham Zegzouti , Nidhi Nath , Subhanjan Mondal , Said Goueli , Poncho Meisenheimer , Thomas Kirkland , James Unch , Dileep K. Pulukkunat , Matthew Robers , Melanie Dart , Thomas Machleidt
- 申请人： Promega Corporation
- 申请人地址： US WI Madison
- 专利权人： Promega Corporation
- 当前专利权人： Promega Corporation
- 当前专利权人地址： US WI Madison
- 代理商 Casimir Jones SC; David Staple
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; C07K14/435 ; C12Q1/66 ; G01N33/533 ; A61K51/08 ; C12N9/02 ; G01N33/542 ; G01N33/58
摘要：
Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
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