Invention Grant
- Patent Title: Production of tissue engineered heart valves
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Application No.: US14987601Application Date: 2016-01-04
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Publication No.: US09801713B2Publication Date: 2017-10-31
- Inventor: Anthony Atala , James Yoo
- Applicant: Wake Forest University Health Sciences
- Applicant Address: US NC Winston-Salem
- Assignee: Wake Forest University Health
- Current Assignee: Wake Forest University Health
- Current Assignee Address: US NC Winston-Salem
- Agency: Pepper Hamilton LLP
- Agent Thomas J. Engellenner; Reza Mollaaghababa
- Main IPC: C12N5/00
- IPC: C12N5/00 ; A61F2/24 ; C12N5/071 ; A61L27/36 ; A61L27/38 ; A61L27/50 ; B82Y5/00 ; B82Y10/00
Abstract:
The invention is directed to methods for preparing artificial heart valves by preconditioning a matrix seeded with endothelial cells and smooth muscle cells differentiated from isolated progenitor cells. These cell seeded matrices are exposed to fluid conditions that mimic blood flow through the heart to produce tissue engineered heart valves that are analogous to native heart valves.
Public/Granted literature
- US20160199179A1 Production Of Tissue Engineered Heart Valves Public/Granted day:2016-07-14
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