- 专利标题: Aryl-quinoline derivatives
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申请号: US14938005申请日: 2015-11-11
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公开(公告)号: US09809599B2公开(公告)日: 2017-11-07
- 发明人: Simona M. Ceccarelli , Aurelia Conte , Holger Kuehne , Bernd Kuhn , Werner Neidhart , Ulrike Obst Sander , Markus Rudolph
- 申请人: Hoffmann-La Roche Inc.
- 申请人地址: US NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Nutley
- 优先权: EP11187967 20111104
- 主分类号: C07D215/00
- IPC分类号: C07D215/00 ; C07D215/02 ; C07D215/54 ; C07D401/04 ; C07D413/04 ; C07D491/048 ; C07D401/14 ; C07D215/227 ; C07D413/14
摘要:
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.
公开/授权文献
- US20160060270A1 New Aryl-Quinoline Derivatives 公开/授权日:2016-03-03
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