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1.发明申请公开(公告)号：US20190144457A1
公开(公告)日：2019-05-16
申请号：US16226363
申请日：2018-12-19
发明人： Patrick Di Giorgio , Jerome Hert , Daniel Hunziker , Holger Kuehne , Patrizio Mattei , Markus Rudolph
IPC分类号： C07D487/04 , C07D519/00
摘要： Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
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2.发明申请BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS 有权双酚化合物（ATX）和赖氨酸（LPA）生产抑制剂公开(公告)号：US20170008900A1
公开(公告)日：2017-01-12
申请号：US15272114
申请日：2016-09-21
发明人： Patrick Di Giorgio , Jerome Hert , Daniel Hunziker , Holger Kuehne , Patrizio Mattei , Markus Rudolph
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
摘要翻译： 其中R 1，R 2，A，W，m，n，p和q如本文所述，包括该化合物的组合物和使用该化合物作为自分生素抑制剂的方法。
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公开(公告)号：US09708340B2
公开(公告)日：2017-07-18
申请号：US14856325
申请日：2015-09-16
发明人： Bernd Buettelmann , Simona M. Ceccarelli , Aurelia Conte , Holger Kuehne , Bernd Kuhn , Werner Neidhart , Ulrike Obst Sander , Hans Richter
IPC分类号： C07D211/00 , C07D295/00 , A61K31/445 , C07D495/04 , C07D213/79 , C07D401/12 , C07D409/12 , C07D205/04 , C07D207/16 , C07D277/06 , C07D209/52 , C07D211/60
CPC分类号： C07D495/04 , C07D205/04 , C07D207/16 , C07D209/52 , C07D211/60 , C07D213/79 , C07D277/06 , C07D401/12 , C07D409/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, W, A and B are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09604977B2
公开(公告)日：2017-03-28
申请号：US14574950
申请日：2014-12-18
发明人： Bernd Buettelmann , Simona M. Ceccarelli , Holger Kuehne , Bernd Kuhn , Werner Neidhart , Ulrike Obst Sander , Hans Richter
IPC分类号： C07D333/50 , C07D333/66 , C07D417/04 , C07D413/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D495/04 , C07D495/10 , C07D413/04
CPC分类号： C07D417/04 , C07D333/50 , C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D495/04 , C07D495/10
摘要： Compounds having the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and methods of using the compounds as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors for the treatment or prophylaxis of type 2 diabetes, atherosclerosis, chronic kidney diseases, non-alcoholic steatohepatitis and cancer.
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![CONDENSED [1,4] DIAZEPINE COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS](/abs-image/US/2017/01/12/US20170008913A1/abs.jpg.150x150.jpg)
5.发明申请CONDENSED [1,4] DIAZEPINE COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS 审中-公开浓缩[1,4]双酚化合物作为自动生成（ATX）和赖氨酸（LPA）生产抑制剂公开(公告)号：US20170008913A1
公开(公告)日：2017-01-12
申请号：US15272085
申请日：2016-09-21
发明人： Daniel Hunziker , Jerome Hert , Holger Kuehne , Patrizio Mattei , Markus Rudolph
IPC分类号： C07D519/00
摘要： Compounds of formula (I) wherein R1, R2, A1 and A2 are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
摘要翻译： 其中R1，R2，A1和A2如本文所述，包括该化合物的组合物和使用该化合物作为自分泌素抑制剂的方法。
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公开(公告)号：US09353102B2
公开(公告)日：2016-05-31
申请号：US14645012
申请日：2015-03-11
发明人： Bernd Buettelmann , Simona M. Ceccarelli , Holger Kuehne , Bernd Kuhn , Werner Neidhart , Ulrike Obst Sander , Hans Richter
IPC分类号： C07D417/04 , C07D417/14 , C07D413/04 , C07D413/14 , C07D333/36
CPC分类号： C07D417/14 , C07D333/36 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，A，E和n如本文所述，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：US20150183778A1
公开(公告)日：2015-07-02
申请号：US14645012
申请日：2015-03-11
发明人： Bernd Buettelmann , Simona M. Ceccarelli , Holger Kuehne , Bernd Kuhn , Werner Neidhart , Ulrike Obst Sander , Hans Richter
IPC分类号： C07D417/14 , C07D413/14 , C07D333/36 , C07D413/04 , C07D417/04
CPC分类号： C07D417/14 , C07D333/36 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，A，E和n如本文所述，包括该化合物的组合物和使用该化合物的方法。
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8.发明授权公开(公告)号：US11098048B2
公开(公告)日：2021-08-24
申请号：US16827136
申请日：2020-03-23
发明人： Patrick Di Giorgio , Jerome Hert , Daniel Hunziker , Holger Kuehne , Patrizio Mattei , Markus Rudolph
IPC分类号： C07D487/04 , A61P3/00 , A61P1/16 , C07D519/00
摘要： Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
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9.发明申请公开(公告)号：US20180111941A1
公开(公告)日：2018-04-26
申请号：US15717724
申请日：2017-09-27
发明人： Patrick Di Giorgio , Jerome Hert , Daniel Hunziker , Holger Kuehne , Patrizio Mattei , Markus Rudolph
IPC分类号： C07D487/04 , C07D519/00
摘要： Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
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10.发明授权公开(公告)号：US09802944B2
公开(公告)日：2017-10-31
申请号：US15272114
申请日：2016-09-21
发明人： Patrick Di Giorgio , Jerome Hert , Daniel Hunziker , Holger Kuehne , Patrizio Mattei , Markus Rudolph
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
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