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公开(公告)号：US11059794B2
公开(公告)日：2021-07-13
申请号：US16569475
申请日：2019-09-12
发明人： Patrizio Mattei , Jérôme Hert , Daniel Hunziker , Markus Rudolph , Petra Schmitz , Patrick Di Giorgio , Justin Gomme
IPC分类号： C07D257/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, X, W, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US10800786B2
公开(公告)日：2020-10-13
申请号：US16380909
申请日：2019-04-10
发明人： Patrizio Mattei , Jerome Hert , Daniel Hunziker , Markus Rudolph , Petra Schmitz , Patrick Di Giorgio
IPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US10435407B2
公开(公告)日：2019-10-08
申请号：US16266782
申请日：2019-02-04
发明人： Bernd Buettelmann , Buelent Kocer , Bernd Kuhn , Marco Prunotto , Hans Richter , Martin Ritter , Markus Rudolph , Alexander Lee Satz
IPC分类号： C07D471/10 , A61P35/00 , A61P13/12 , A61P37/06 , A61P9/00 , A61P1/16 , C07D519/00
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
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公开(公告)号：US09656971B2
公开(公告)日：2017-05-23
申请号：US14752177
申请日：2015-06-26
发明人： Caterina Bissantz , René Bonnafous , Bernd Buettelmann , Roland Jakob-Roetne , Christian Lerner , Markus Rudolph
IPC分类号： C07D239/88 , C07D471/04 , C07D417/10 , C07D417/04 , C07D413/04 , C07D409/04 , C07D409/06 , C07D409/14 , C07D405/04 , C07D403/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D401/06
CPC分类号： C07D239/88 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/10 , C07D471/04
摘要： The present invention relates to compounds of formula wherein the substituents are described in claim 1 and to the pharmaceutically acceptable salts thereof. These compounds inhibit the enzyme catechol-O-methyltransferase (COMT). The compounds may be used for the treatment of Parkinson's disease, depression, cognitive impairment and motor symptoms, resistant depression, cognitive impairment, mood and negative symptoms of schizophrenia.
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![CONDENSED [1,4] DIAZEPINE COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS](/abs-image/US/2017/01/12/US20170008913A1/abs.jpg.150x150.jpg)
5.发明申请CONDENSED [1,4] DIAZEPINE COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS 审中-公开浓缩[1,4]双酚化合物作为自动生成（ATX）和赖氨酸（LPA）生产抑制剂公开(公告)号：US20170008913A1
公开(公告)日：2017-01-12
申请号：US15272085
申请日：2016-09-21
发明人： Daniel Hunziker , Jerome Hert , Holger Kuehne , Patrizio Mattei , Markus Rudolph
IPC分类号： C07D519/00
摘要： Compounds of formula (I) wherein R1, R2, A1 and A2 are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
摘要翻译： 其中R1，R2，A1和A2如本文所述，包括该化合物的组合物和使用该化合物作为自分泌素抑制剂的方法。
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公开(公告)号：US10889588B2
公开(公告)日：2021-01-12
申请号：US16889322
申请日：2020-06-01
发明人： Jerome Hert , Daniel Hunziker , Patrizio Mattei , Markus Rudolph , Petra Schmitz , Christoph Ullmer
IPC分类号： C07D487/04 , A61P27/02 , A61K31/407
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R9, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US10882857B2
公开(公告)日：2021-01-05
申请号：US16569459
申请日：2019-09-12
发明人： Jérôme Hert , Daniel Hunziker , Patrizio Mattei , Markus Rudolph , Petra Schmitz , Patrick Di Giorgio
IPC分类号： C07D471/04 , C07D405/14 , A61K9/20 , A61K9/48 , C07D498/04 , C07D401/14 , C07D495/04 , C07D513/04 , C07D519/00
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
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![Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl](/abs-image/US/2020/12/01/US10849881B2/abs.jpg.150x150.jpg)
公开(公告)号：US10849881B2
公开(公告)日：2020-12-01
申请号：US15997341
申请日：2018-06-04
发明人： Patrizio Mattei , Daniel Hunziker , Patrick Di Giorgio , Jerome Hert , Markus Rudolph , Lisha Wang
IPC分类号： A61K31/407 , C07D209/56 , C07D487/04
摘要： The invention provides novel compounds having the general formula (I) wherein R1, Y and R2 are as described herein, compositions including the compounds and methods of using the compounds.
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9.发明授权公开(公告)号：US10654857B2
公开(公告)日：2020-05-19
申请号：US16226363
申请日：2018-12-19
发明人： Patrick Di Giorgio , Jerome Hert , Daniel Hunziker , Holger Kuehne , Patrizio Mattei , Markus Rudolph
IPC分类号： C07D487/04 , A61P3/00 , A61P1/16 , C07D519/00
摘要： Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
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公开(公告)号：US20160002177A1
公开(公告)日：2016-01-07
申请号：US14752177
申请日：2015-06-26
发明人： Caterina BISSANTZ , René Bonnafous , Bernd Buettelmann , Roland Jakob-Roetne , Christian Lerner , Markus Rudolph
IPC分类号： C07D239/88 , C07D403/10 , C07D403/04 , C07D405/04 , C07D409/04 , C07D401/12 , C07D401/10 , C07D413/04 , C07D401/06 , C07D471/04 , C07D409/14 , C07D409/06 , C07D401/04 , C07D417/04
CPC分类号： C07D239/88 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/10 , C07D471/04
摘要： The present invention relates to compounds of formula wherein the substituents are described in claim 1 and to the pharmaceutically acceptable salts thereof.These compounds inhibit the enzyme catechol-O-methyltransferase (COMT). The compounds may be used for the treatment of Parkinson's disease, depression, cognitive impairment and motor symptoms, resistant depression, cognitive impairment, mood and negative symptoms of schizophrenia.
摘要翻译： 本发明涉及下式的化合物，其中取代基如权利要求1所述及其药学上可接受的盐。 这些化合物抑制儿茶酚-O-甲基转移酶（COMT）。 该化合物可用于治疗帕金森病，抑郁症，认知障碍和运动症状，耐药性抑郁症，认知障碍，情绪和精神分裂症阴性症状。
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