Invention Grant
- Patent Title: Method for preparing 3-trifluoromethyl chalcones
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Application No.: US15455691Application Date: 2017-03-10
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Publication No.: US09834523B2Publication Date: 2017-12-05
- Inventor: Gary David Annis
- Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
- Applicant Address: US DE Wilmington
- Assignee: E.I. du Pont de Nemours and Company
- Current Assignee: E.I. du Pont de Nemours and Company
- Current Assignee Address: US DE Wilmington
- Main IPC: C07D261/04
- IPC: C07D261/04 ; C07C49/80 ; C07C17/35 ; C07C25/13 ; C07C67/343 ; C07C205/45 ; C07C231/12 ; C07D213/40 ; C07D249/08 ; C07D249/10 ; C07D277/28 ; C07C209/74 ; C07C45/45 ; C07C45/70 ; C07C49/813 ; C07C231/14 ; C07D231/12 ; C07D231/14 ; C07D231/16

Abstract:
Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.
Public/Granted literature
- US20170197925A1 METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES Public/Granted day:2017-07-13
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