发明授权
- 专利标题： Compositions and methods for the modulation of DNA damage responses using BAL1 and BBAP
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申请号： US14350166申请日： 2012-10-05
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公开(公告)号： US09840708B2公开(公告)日： 2017-12-12
- 发明人: Margaret A. Shipp , Qingsheng Yan
- 申请人： Dana-Farber Cancer Institute, Inc.
- 申请人地址： US MA Boston
- 专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人地址： US MA Boston
- 代理机构： Foley Hoag LLP
- 国际申请： PCT/US2012/058960 WO 20121005
- 国际公布： WO2013/052800 WO 20130411
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; C12N15/85 ; C12Q1/68 ; G01N33/574 ; C07K16/40 ; C12N9/10 ; C12N9/00 ; C12Q1/25 ; C12Q1/48 ; G01N33/573
摘要：
The invention provides methods and compositions for enhancing the efficacy of cancer therapies through modulation of BAL1 and/or BBAP. Also provided are methods for predicting the efficacy of cancer therapies or treating cancer in a subject through modulation of BAL1 and/or BBAP. Further provided are methods for identifying compounds that are capable of modulating BAL1-BBAP complexes.
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