Invention Grant
- Patent Title: Combinations of a photosensitizer with a hydrogen sulfide donor, thioredoxin inhibitor or nitroxide for use in photodynamic therapy
-
Application No.: US15315699Application Date: 2015-06-02
-
Publication No.: US09919049B2Publication Date: 2018-03-20
- Inventor: Mark Elliott Wood , Paul Graham Winyard , Daniel Colin Jeremy Ferguson , Matthew Whiteman , Alison Curnow , Alexis Perry
- Applicant: UNIVERSITY OF EXETER
- Applicant Address: GB Exeter
- Assignee: University of Exeter
- Current Assignee: University of Exeter
- Current Assignee Address: GB Exeter
- Priority: GB1409792.7 20140602; GB1418676.1 20141021
- International Application: PCT/GB2015/051608 WO 20150602
- International Announcement: WO2015/185918 WO 20151210
- Main IPC: A61K41/00
- IPC: A61K41/00 ; A61K31/67

Abstract:
Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.
Public/Granted literature
Information query