公开(公告)号：US09919049B2

公开(公告)日：2018-03-20

申请号：US15315699

申请日：2015-06-02

Applicant: UNIVERSITY OF EXETER

Inventor： Mark Elliott Wood ,  Paul Graham Winyard ,  Daniel Colin Jeremy Ferguson ,  Matthew Whiteman ,  Alison Curnow ,  Alexis Perry

IPC: A61K41/00 ,  A61K31/67

CPC classification number: A61K41/0061 ,  A61K31/385 ,  A61K31/44 ,  A61K31/445 ,  A61K31/454 ,  A61K31/67 ,  A61K31/7135 ,  A61K33/24 ,  A61K41/0071 ,  A61K47/54

Abstract: Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.

公开(公告)号：US10149907B2

公开(公告)日：2018-12-11

申请号：US15890576

申请日：2018-02-07

Applicant: UNIVERSITY OF EXETER

Inventor： Mark Elliott Wood ,  Paul Graham Winyard ,  Daniel Colin Jeremy Ferguson ,  Matthew Whiteman ,  Alison Curnow ,  Alexis Perry

IPC: A61K41/00 ,  A61K31/385 ,  A61K31/44 ,  A61K31/7135 ,  A61K33/24 ,  A61K31/445 ,  A61K31/454 ,  A61K31/67 ,  A61K47/54

Abstract: The invention relates to a combination comprising(i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.