公开(公告)号：US09919049B2

公开(公告)日：2018-03-20

申请号：US15315699

申请日：2015-06-02

Applicant: UNIVERSITY OF EXETER

Inventor： Mark Elliott Wood ,  Paul Graham Winyard ,  Daniel Colin Jeremy Ferguson ,  Matthew Whiteman ,  Alison Curnow ,  Alexis Perry

IPC: A61K41/00 ,  A61K31/67

CPC classification number: A61K41/0061 ,  A61K31/385 ,  A61K31/44 ,  A61K31/445 ,  A61K31/454 ,  A61K31/67 ,  A61K31/7135 ,  A61K33/24 ,  A61K41/0071 ,  A61K47/54

Abstract: Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.

公开(公告)号：US10149907B2

公开(公告)日：2018-12-11

申请号：US15890576

申请日：2018-02-07

Applicant: UNIVERSITY OF EXETER

Inventor： Mark Elliott Wood ,  Paul Graham Winyard ,  Daniel Colin Jeremy Ferguson ,  Matthew Whiteman ,  Alison Curnow ,  Alexis Perry

IPC: A61K41/00 ,  A61K31/385 ,  A61K31/44 ,  A61K31/7135 ,  A61K33/24 ,  A61K31/445 ,  A61K31/454 ,  A61K31/67 ,  A61K47/54

Abstract: The invention relates to a combination comprising(i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.

公开(公告)号：US09346758B2

公开(公告)日：2016-05-24

申请号：US14425385

申请日：2013-09-02

Applicant: UNIVERSITY OF EXETER

Inventor： Alison Curnow ,  Mark Wood ,  Alexis Perry

IPC: C07D213/69 ,  A61K31/4412 ,  A61K41/00 ,  A61K49/00 ,  A61K8/49 ,  A61Q19/00

CPC classification number: C07D213/69 ,  A61K8/4926 ,  A61K41/0057 ,  A61K49/0021 ,  A61K2800/81 ,  A61Q19/00

Abstract: A compound which is a compound of formula (I) or any salt thereof: wherein R1 is a Ci-C6 alkyl group, R2 is H or a Ci-C6 alkyl group, R3 is H or a Ci-C6 alkyl group, and n is an integer from 0 to 5.

Abstract translation: 化合物，其为式（I）化合物或其盐：其中R 1为C 1 -C 6烷基，R 2为H或C 1 -C 6烷基，R 3为H或C 1 -C 6烷基，n为 是从0到5的整数。

公开(公告)号：US20150196034A1

公开(公告)日：2015-07-16

申请号：US14347782

申请日：2012-10-01

Applicant: THE UNIVERSITY OF EXETER

Inventor： Mark Wood ,  Matthew Whiteman ,  Alexis Perry

IPC: A01N57/24 ,  C07F9/54 ,  C07F9/6553

CPC classification number: A01N57/24 ,  A61K31/385 ,  A61K31/662 ,  A61K47/54 ,  C07F9/5442 ,  C07F9/655345

Abstract: The invention relates to a compound comprising a mitochondrial targeting group linked to group capable of releasing hydrogen sulfide, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body by surgery or therapy. The invention also relates to the use of the compound in the treatment of a plant, and to certain forms of the compound.

Abstract translation: 本发明涉及包含与能够释放硫化氢的基团连接的线粒体靶向基团的化合物或其药学上可接受的盐，用于通过手术或治疗来治疗人或动物体。 本发明还涉及该化合物在处理植物和某些形式的化合物中的用途。

公开(公告)号：US10058100B2

公开(公告)日：2018-08-28

申请号：US14347782

申请日：2012-10-01

Applicant: THE UNIVERSITY OF EXETER

Inventor： Mark Wood ,  Matthew Whiteman ,  Alexis Perry

IPC: A01N57/24 ,  C07F9/54 ,  C07F9/6553 ,  A61K31/662 ,  A61K47/48 ,  A61K31/385

CPC classification number: A01N57/24 ,  A61K31/385 ,  A61K31/662 ,  A61K47/54 ,  C07F9/5442 ,  C07F9/655345

Abstract: The invention relates to a compound comprising a mitochondrial targeting group linked to group capable of releasing hydrogen sulfide, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body by surgery or therapy. The invention also relates to the use of the compound in the treatment of a plant, and to certain forms of the compound.

公开(公告)号：US20150210642A1

公开(公告)日：2015-07-30

申请号：US14425385

申请日：2013-09-02

Applicant: UNIVERSITY OF EXETER

Inventor： Alison Curnow ,  Mark Wood ,  Alexis Perry

IPC: C07D213/69

CPC classification number: C07D213/69 ,  A61K8/4926 ,  A61K41/0057 ,  A61K49/0021 ,  A61K2800/81 ,  A61Q19/00

Abstract: A compound which is a compound of formula (I) or any salt thereof: wherein R1 is a Ci-C6 alkyl group, R2 is H or a Ci-C6 alkyl group, R3 is H or a Ci-C6 alkyl group, and n is an integer from 0 to 5.

Abstract translation: 化合物，其为式（I）化合物或其盐：其中R 1为C 1 -C 6烷基，R 2为H或C 1 -C 6烷基，R 3为H或C 1 -C 6烷基，n为 是从0到5的整数。