Apparatus and methods for overvoltage switches with active leakage current compensation are provided. In certain configurations, an IC includes an input node and a protection device or overvoltage switch electrically connected to the input node. The protection device includes a first well and a second well. The second well is positioned adjacent to the first well and has a conductivity type opposite that of the first well. Additionally, a first terminal of the protection device is electrically connected to the first well and to the input node of the IC. The protection device further includes a leakage current compensation circuit that is used to control a voltage level of the second well based on a voltage level of the first terminal to inhibit a leakage current of the first terminal of the protection device.