- 专利标题: Benzimidazole and imadazopyridine carboximidamide compounds
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申请号: US15153527申请日: 2016-05-12
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公开(公告)号: US09951065B2公开(公告)日: 2018-04-24
- 发明人: Mark J. Bartlett , Julian Andrew Codelli , Britton Kenneth Corkey , Jennifer Leigh Cosman , Kristyna Elbel , Jennifer Alissa Loyer-Drew , David Sperandio , Joshua Van Veldhuizen , Hai Yang , Suet Chung Yeung
- 申请人: Gilead Sciences, Inc.
- 申请人地址: US CA Foster City
- 专利权人: Gilead Sciences, Inc.
- 当前专利权人: Gilead Sciences, Inc.
- 当前专利权人地址: US CA Foster City
- 主分类号: C07D235/06
- IPC分类号: C07D235/06 ; C07D235/24 ; C07D295/125 ; C07D401/12 ; C07D471/04 ; A61K45/06 ; C07D235/08 ; A61K31/4184 ; A61K31/5377 ; A61K31/454 ; A61K31/437 ; A61K31/506 ; A61K31/497 ; A61K31/55 ; A61K31/541 ; A61K31/439 ; C07D405/12 ; C07D405/14 ; C07D471/08 ; A61K31/553 ; C07D235/30 ; C07D235/14 ; C07D401/04 ; C07D235/12 ; A61K31/444 ; A61K31/4545 ; A61K31/538 ; A61K31/5386 ; A61K31/438 ; C07D403/12 ; A61K31/4439 ; C07D413/12 ; A61K31/496 ; C07D487/04 ; A61K31/4725 ; C07D235/28 ; C07D235/16 ; C07D409/12
摘要:
The present disclosure provides indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors of Formula I: or pharmaceutically acceptable salts thereof, in which X, L, n, m, R1, R2a, R2b, Rn, Rm, and Rt are as defined herein, as well as pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using the same to treat conditions mediated by IDO1.
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