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公开(公告)号：US11229638B2
公开(公告)日：2022-01-25
申请号：US16641166
申请日：2018-08-20
发明人： Mark J. Bartlett , Britton Kenneth Corkey , Jennifer Leigh Cosman , Kristyna M. Elbel , Elfatih Elzein , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Eric Q. Parkhill , Thao Perry
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4745 , C07D487/04 , A61P35/00 , A61K31/497 , A61K35/17 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K35/26 , A61K39/395 , A61K45/06 , C07K16/28
摘要： Compounds having the following Formula I and/or Formula II and methods of their use and preparation are disclosed:
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公开(公告)号：US20200031834A1
公开(公告)日：2020-01-30
申请号：US16502721
申请日：2019-07-03
发明人： Mark J. Bartlett , Britton Kenneth Corkey , Kristyna M. Elbel , Rao V. Kalla , Xiaofen Li , Thao Perry
IPC分类号： C07D487/04 , C07D471/04
摘要： Compounds having the following Formula (I), or a pharmaceutically acceptable salt or pharmaceutically acceptable tautomer thereof, and methods of their use and preparation are disclosed:
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公开(公告)号：US11780844B2
公开(公告)日：2023-10-10
申请号：US18117858
申请日：2023-03-06
发明人： Mark J. Bartlett , Daniel H. Byun , Yifan Deng , Jennifer L. Cosman Ellis , Rao V. Kalla , Richard L. Mackman , Dustin S. Siegel , Xianhuang Zeng
IPC分类号： C07D487/04 , A61P31/14
CPC分类号： C07D487/04 , A61P31/14
摘要： Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
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公开(公告)号：US20230279013A1
公开(公告)日：2023-09-07
申请号：US18117858
申请日：2023-03-06
发明人： Mark J. Bartlett , Daniel H. Byun , Yifan Deng , Jennifer L. Cosman Ellis , Rao V. Kalla , Richard L. Mackman , Dustin S. Siegel , Xianhuang Zeng
IPC分类号： C07D487/04 , A61P31/14
CPC分类号： C07D487/04 , A61P31/14
摘要： Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
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公开(公告)号：US20230013585A1
公开(公告)日：2023-01-19
申请号：US17331900
申请日：2021-05-27
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman , Rao V. Kalla , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： A61K31/4545 , A61K31/444 , A61K31/5386 , C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US20220213091A1
公开(公告)日：2022-07-07
申请号：US17522628
申请日：2021-11-09
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman , Rao V. Kalla , Zachary A. Kasun , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Sundaramoorthi Swaminathan , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US11925631B2
公开(公告)日：2024-03-12
申请号：US17331900
申请日：2021-05-27
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman , Rao V. Kalla , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/5386 , C07D471/04 , C07D519/00 , C12Q1/00
CPC分类号： A61K31/4545 , A61K31/444 , A61K31/5386 , C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US11897878B2
公开(公告)日：2024-02-13
申请号：US17522628
申请日：2021-11-09
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L Cosman , Rao V. Kalla , Zachary A. Kasun , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Sundaramoorthi Swaminathan , Joshua J. Van Veldhuizen , Suet C Yeung , Jeff Zablocki
IPC分类号： C07D471/04 , A61K31/437 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US20240043427A1
公开(公告)日：2024-02-08
申请号：US17997594
申请日：2021-04-29
发明人： Mark J. Bartlett , Gregory F. Chin , Michael O. Clarke , Jennifer L. Cosman , Deeba Ensan , Bindu Goyal , Stephen Ho , Hon C. Hui , Richard L. Mackman , Michael R. Mish , Scott D. Schroeder , Nathan D. Shapiro , Dustin S. Siegel , Doris T. Tang , Hai Yang
IPC分类号： C07D487/04 , C07D519/00 , A61K45/06 , C07K16/28
CPC分类号： C07D487/04 , C07D519/00 , C07K16/2827 , C07K16/2818 , A61K45/06
摘要： The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.
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公开(公告)号：US11186579B2
公开(公告)日：2021-11-30
申请号：US16502721
申请日：2019-07-03
发明人： Mark J. Bartlett , Britton Kenneth Corkey , Kristyna M. Elbel , Rao V. Kalla , Xiaofen Li , Thao Perry
IPC分类号： C07D487/04 , C07D471/04 , A61K31/519
摘要： Compounds having the following Formula (I), or a pharmaceutically acceptable salt or pharmaceutically acceptable tautomer thereof, and methods of their use and preparation are disclosed:
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