- 专利标题: FAP-activated proteasome inhibitors for treating solid tumors
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申请号: US15167109申请日: 2016-05-27
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公开(公告)号: US09956297B2公开(公告)日: 2018-05-01
- 发明人: William W. Bachovchin , Hung-sen Lai , Sarah E. Poplawski
- 申请人: Trustees of Tufts College
- 申请人地址: US MA Boston
- 专利权人: Trustees of Tufts College
- 当前专利权人: Trustees of Tufts College
- 当前专利权人地址: US MA Boston
- 代理机构: Foley Hoag LLP
- 主分类号: A61K31/69
- IPC分类号: A61K31/69 ; A61K47/48 ; A61K45/06 ; G01N33/574 ; C07K5/083 ; C07K5/087 ; C07K5/097 ; C07K5/107 ; C07K5/065 ; C07K5/062 ; A61K38/07 ; A61K47/54 ; A61K38/00
摘要:
Disclosed are proteasome inhibitors, fibroblast activation protein (FAP)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods of using the inhibitors and prodrugs and compositions thereof, for example, in treating cancer or other cell proliferative diseases. In vitro and in vivo methods of quantifying the expression of FAP in a biopsy sample and a mammal, respectively, are also disclosed.
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