A system for analyzing driver fitness to drive with consideration given to any of various conditions such as driver drowsiness, fatigue, and anxiety. The system includes a processing hardware unit, and a non-transitory computer-readable storage device comprising various modules to determine if the driver is impaired. The modules include an input interface module that, when executed by the processing unit, receives sensor data indicating a present driver health factor. A database module includes pre-established driver-profile data particular to a driver. And the modules include an activity module that, when executed by the processing unit, obtains the driver-profile data and the sensor data, and determines, based on the present health factor and the pre-established driver-profile data, fitness of the driver to drive. The disclosure relates in various embodiments to a computer-readable storage device, separately, and processes performed by the system and device.