Invention Grant
- Patent Title: Vivo detection of phospholipase activation
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Application No.: US12920451Application Date: 2009-03-03
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Publication No.: US09957546B2Publication Date: 2018-05-01
- Inventor: E. J. Delikatny , Anatoliy V. Popov , Gang Zheng , Theresa Mawn
- Applicant: E. J. Delikatny , Anatoliy V. Popov , Gang Zheng , Theresa Mawn
- Applicant Address: US PA Philadelphia
- Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee Address: US PA Philadelphia
- Agency: Pearl Cohen Zedek Latzer Baratz LLP
- Agent Mark S. Cohen
- International Application: PCT/US2009/035822 WO 20090303
- International Announcement: WO2009/111439 WO 20090911
- Main IPC: A61B5/00
- IPC: A61B5/00 ; A61B8/00 ; A61B10/00 ; C12Q1/61 ; A61K49/00 ; G01N33/50 ; G01N33/542 ; G01N33/574 ; A61K41/00
Abstract:
The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided herein is methods of analyzing a sample for the presence of a phospholipase and methods of identifying the activity of a phospholipase in vivo utilizing phospholipid-based NIR molecular beacon.
Public/Granted literature
- US20110165084A1 VIVO DETECTION OF PHOSPHOLIPASE ACTIVATION Public/Granted day:2011-07-07
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