A cellular radio architecture that includes a programmable bandpass sampling radio frequency front-end and an optimized digital baseband. The architecture includes a receiver module having a plurality of signal channels for different frequency bands, where each signal channel in the receiver module includes a receiver delta-sigma modulator that converts analog receive signals to a representative digital signal. The architecture also includes a transmitter module having a transmitter delta-sigma modulator for converting digital data bits to analog transmit signals, where the transmitter module includes a power amplifier and a switch for directing the transmit signals to one of the signal paths. The architecture also includes a dual self-cancellation circuit providing digital and analog cancellation of the transmit signal in the receiver module.