再颁专利
USRE44638E1 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
有权
喹唑啉酮作为人磷脂酰肌醇3-激酶三角体的抑制剂
- 专利标题： Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
- 专利标题（中）： 喹唑啉酮作为人磷脂酰肌醇3-激酶三角体的抑制剂
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申请号： US13730256申请日： 2012-12-28
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公开(公告)号： USRE44638E1公开(公告)日： 2013-12-10
- 发明人: Kerry W. Fowler , Danwen Huang , Edward A. Kesicki , Hua Chee Ooi , Amy Oliver , Fuqiang Ruan , Jennifer Treiberg , Kamal Deep Puri
- 申请人： Kerry W. Fowler , Danwen Huang , Edward A. Kesicki , Hua Chee Ooi , Amy Oliver , Fuqiang Ruan , Jennifer Treiberg , Kamal Deep Puri
- 申请人地址： US IN Indianapolis
- 专利权人： ICOS Corporation
- 当前专利权人： ICOS Corporation
- 当前专利权人地址： US IN Indianapolis
- 代理机构： Morrison & Foerster LLP
- 国际申请： PCT/US2005/016778 WO 20050512
- 国际公布： WO2005/113556 WO 20051201
- 主分类号： A61K31/517
- IPC分类号： A61K31/517
摘要：
The invention provides a class of substituted quinazolinone compounds and methods of treating diseases mediated by PI3Kδ activity. The disclosed compounds are useful in treating diseases such as bone-resorption disorders; and cancer, especially hematopoietic cancers, lymphomas, multiple myelomas and leukemia. The compounds are also useful in disrupting or inhibiting cellular processes such as leukocyte function or accumulation, neutrophils function, lymphocyte proliferation, and endogenous immune responses.
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