Invention Application
- Patent Title: NUCLEIC ACID MOLECULES, POLYPEPTIDES AND USES THEREFOR, INCLUDING DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE
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Application No.: PCT/US2002/031642Application Date: 2002-10-03
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Publication No.: WO2003028543A3Publication Date: 2003-04-10
- Inventor: DURHAM, L., Kathryn , FRIEDMAN, David, L. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , KIMMEL, Lida, H. , PAREKH, Rajesh, Bhikhu , POTTER, David, M. , ROHLFF, Christian , SILBER, B., Michael , SNYDER, Peter, Jeffrey , SOARES, Holly, Daria , STIGER, Thomas, R. , SUNDERLAND, P., Trey , TOWNSEND, Robert, Reid , WHITE, W., Frost , WILLIAMS, Stephen, A.
- Applicant: PFIZER PRODUCTS INC. , OXFORD GLYCOSCIENCES (UK) LTD. , DURHAM, L., Kathryn , FRIEDMAN, David, L. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , KIMMEL, Lida, H. , PAREKH, Rajesh, Bhikhu , POTTER, David, M. , ROHLFF, Christian , SILBER, B., Michael , SNYDER, Peter, Jeffrey , SOARES, Holly, Daria , STIGER, Thomas, R. , SUNDERLAND, P., Trey , TOWNSEND, Robert, Reid , WHITE, W., Frost , WILLIAMS, Stephen, A.
- Applicant Address: Eastern Point Road, Groton, CT 06340-5196 US
- Assignee: PFIZER PRODUCTS INC.,OXFORD GLYCOSCIENCES (UK) LTD.,DURHAM, L., Kathryn,FRIEDMAN, David, L.,HERATH, Herath, Mudiyanselage, Athula, Chandrasiri,KIMMEL, Lida, H.,PAREKH, Rajesh, Bhikhu,POTTER, David, M.,ROHLFF, Christian,SILBER, B., Michael,SNYDER, Peter, Jeffrey,SOARES, Holly, Daria,STIGER, Thomas, R.,SUNDERLAND, P., Trey,TOWNSEND, Robert, Reid,WHITE, W., Frost,WILLIAMS, Stephen, A.
- Current Assignee: PFIZER PRODUCTS INC.,OXFORD GLYCOSCIENCES (UK) LTD.,DURHAM, L., Kathryn,FRIEDMAN, David, L.,HERATH, Herath, Mudiyanselage, Athula, Chandrasiri,KIMMEL, Lida, H.,PAREKH, Rajesh, Bhikhu,POTTER, David, M.,ROHLFF, Christian,SILBER, B., Michael,SNYDER, Peter, Jeffrey,SOARES, Holly, Daria,STIGER, Thomas, R.,SUNDERLAND, P., Trey,TOWNSEND, Robert, Reid,WHITE, W., Frost,WILLIAMS, Stephen, A.
- Current Assignee Address: Eastern Point Road, Groton, CT 06340-5196 US
- Agency: ARNOLD, Beth, E.
- Priority: US60/326,708 20011003
- Main IPC: C07K5/00
- IPC: C07K5/00
Abstract:
The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
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