公开(公告)号：WO2003032894A3

公开(公告)日：2003-04-24

申请号：PCT/IB2002/003775

申请日：2002-09-13

Applicant: PFIZER PRODUCTS INC. ,  CHENARD, Bertrand, Leo ,  FRIEDMAN, David, Lee ,  KIMMEL, Lida, Helen ,  NELMS, Linda, Fay ,  SILBER, Bernie, Michael ,  SOARES, Holly, Daria ,  WHITE, Walter, Frost, Jr.

Inventor： CHENARD, Bertrand, Leo ,  FRIEDMAN, David, Lee ,  KIMMEL, Lida, Helen ,  NELMS, Linda, Fay ,  SILBER, Bernie, Michael ,  SOARES, Holly, Daria ,  WHITE, Walter, Frost, Jr.

IPC: C07K7/00

Abstract: Methods for monitoring and evaluating the efficacy of neuroprotective treatment of a patient suffering from neurological damage by measuring the amount of at least one biomarker in a biological sample taken from the patient during or after treatment.

公开(公告)号：WO2003028543A3

公开(公告)日：2003-04-10

申请号：PCT/US2002/031642

申请日：2002-10-03

Applicant: PFIZER PRODUCTS INC. ,  OXFORD GLYCOSCIENCES (UK) LTD. ,  DURHAM, L., Kathryn ,  FRIEDMAN, David, L. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  KIMMEL, Lida, H. ,  PAREKH, Rajesh, Bhikhu ,  POTTER, David, M. ,  ROHLFF, Christian ,  SILBER, B., Michael ,  SNYDER, Peter, Jeffrey ,  SOARES, Holly, Daria ,  STIGER, Thomas, R. ,  SUNDERLAND, P., Trey ,  TOWNSEND, Robert, Reid ,  WHITE, W., Frost ,  WILLIAMS, Stephen, A.

Inventor： DURHAM, L., Kathryn ,  FRIEDMAN, David, L. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  KIMMEL, Lida, H. ,  PAREKH, Rajesh, Bhikhu ,  POTTER, David, M. ,  ROHLFF, Christian ,  SILBER, B., Michael ,  SNYDER, Peter, Jeffrey ,  SOARES, Holly, Daria ,  STIGER, Thomas, R. ,  SUNDERLAND, P., Trey ,  TOWNSEND, Robert, Reid ,  WHITE, W., Frost ,  WILLIAMS, Stephen, A.

IPC: C07K5/00

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

公开(公告)号：WO2003089928A1

公开(公告)日：2003-10-30

申请号：PCT/IB2003/001382

申请日：2003-04-08

Applicant: PFIZER PRODUCTS INC. ,  BEDIAN, Vahe ,  MCLEAN, Stafford ,  OBACH, Ronald, Scott ,  SOARES, Holly, Daria

Inventor： BEDIAN, Vahe ,  MCLEAN, Stafford ,  OBACH, Ronald, Scott ,  SOARES, Holly, Daria

IPC: G01N33/53

CPC classification number: C07K16/44 ,  C12Q1/26 ,  G01N33/558 ,  Y10T436/173845

Abstract: The present invention provides methods of determining the proper dosage of Compound 122 (and other drugs that are metabolized by cytochrome P450 2D6) to be given to a patient. Also provided are methods of determining the metabolizer status of persons, devices for performing the invention methods, and antibodies for use in these devices and methods.

Abstract translation: 本发明提供了确定给予患者的化合物122（和由细胞色素P450 2D6代谢的其它药物）的适当剂量的方法。 还提供了确定人的代谢状态，用于实施本发明方法的装置和用于这些装置和方法的抗体的方法。

公开(公告)号：WO03032894A2

公开(公告)日：2003-04-24

申请号：PCT/IB0203775

申请日：2002-09-13

Applicant: PFIZER PROD INC ,  CHENARD BERTRAND LEO ,  FRIEDMAN DAVID LEE ,  KIMMEL LIDA HELEN ,  NELMS LINDA FAY ,  SILBER BERNIE MICHAEL ,  SOARES HOLLY DARIA ,  WHITE WALTER FROST JR

Inventor： CHENARD BERTRAND LEO ,  FRIEDMAN DAVID LEE ,  KIMMEL LIDA HELEN ,  NELMS LINDA FAY ,  SILBER BERNIE MICHAEL ,  SOARES HOLLY DARIA ,  WHITE WALTER FROST JR

IPC: G01N33/53 ,  A61K31/445 ,  A61K45/00 ,  A61P3/08 ,  A61P9/10 ,  A61P11/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  C07D211/14 ,  G01N33/15 ,  G01N33/68 ,  A61K

CPC classification number: G01N33/6896 ,  G01N2500/00 ,  G01N2800/52

Abstract: Methods for monitoring and evaluating the efficacy of neuroprotective treatment of a patient suffering from neurological damage by measuring the amount of at least one biomarker in a biological sample taken from the patient during or after treatment.

Abstract translation: 用于通过测量在治疗期间或之后从患者取得的生物样品中至少一种生物标志物的量来监测和评估患有神经损伤的患者的神经保护治疗的功效的方法。

公开(公告)号：WO2003028543A2

公开(公告)日：2003-04-10

申请号：PCT/US2002/031642

申请日：2002-10-03

Applicant: PFIZER PRODUCTS INC. ,  OXFORD GLYCOSCIENCES (UK) LTD. ,  DURHAM, L., Kathryn ,  FRIEDMAN, David, L. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  KIMMEL, Lida, H. ,  PAREKH, Rajesh, Bhikhu ,  POTTER, David, M. ,  ROHLFF, Christian ,  SILBER, B., Michael ,  SNYDER, Peter, Jeffrey ,  SOARES, Holly, Daria ,  STIGER, Thomas, R. ,  SUNDERLAND, P., Trey ,  TOWNSEND, Robert, Reid ,  WHITE, W., Frost ,  WILLIAMS, Stephen, A.

Inventor： DURHAM, L., Kathryn ,  FRIEDMAN, David, L. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  KIMMEL, Lida, H. ,  PAREKH, Rajesh, Bhikhu ,  POTTER, David, M. ,  ROHLFF, Christian ,  SILBER, B., Michael ,  SNYDER, Peter, Jeffrey ,  SOARES, Holly, Daria ,  STIGER, Thomas, R. ,  SUNDERLAND, P., Trey ,  TOWNSEND, Robert, Reid ,  WHITE, W., Frost ,  WILLIAMS, Stephen, A.

IPC: A61B

CPC classification number: G01N33/6896 ,  C07K14/4711 ,  C07K16/18 ,  G01N2333/4709 ,  G01N2500/00 ,  G01N2800/2821 ,  G01N2800/52

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

Abstract translation: 本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和药物开发。 描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默病相关特征（AF）。 本发明进一步提供在脑脊液，血清或血浆中可检测的阿尔茨海默病相关蛋白质异构体（API），包含针对API免疫特异性的分离的API抗体的制剂，药物组合物，诊断和治疗方法以及包含或基于其的试剂盒。